Tg(APOC1)1Lmh
Transgene Detail

Summary

• Symbol: Tg(APOC1)1Lmh
• Name: transgene insertion 1, Louis M Havekes
• MGI ID: MGI:1926379
• Synonyms: 11/1, APOC1
• Transgene: Tg(APOC1)1Lmh Location: unknown
• Alliance: Tg(APOC1)1Lmh page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOC1)1Lmh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOC1 (341)

  Apoc1

  (MGI:88053)

• Mutation details: Overexpression of human apolipoprotein C gene (APOC1) in liver and skin. This is the high expressor line. Northern blots show that APOC1 mRNA levels are 4- to 5-fold elevated in this high expressor mice compared to the low expressor, Tg(APOC1)3Lmh mice. (J:65146)
• Inheritance: Not Specified

Disease models

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

High expressor strain.

References

• Original: J:65146 Jong MC, et al., In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway. J Clin Invest. 1996 Nov 15;98(10):2259-67
• All: 17 reference(s)