About   Help   FAQ
Rassf5 Gene Detail
Summary
  • Symbol
    Rassf5
  • Name
    Ras association (RalGDS/AF-6) domain family member 5
  • Synonyms
    1300019G20Rik, Nore1A, Nore1B, Rapl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926375
    NCBI Gene: 54354
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:131104147-131172915 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 56.91 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1847 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926375
 protein coding gene Chr1:131104147-131172995 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016451
 protein coding gene Chr1:134597817-134668592 (-)
A/J MGP_AJ_G0016434
 protein coding gene Chr1:129625863-129694370 (-)
AKR/J MGP_AKRJ_G0016399
 protein coding gene Chr1:133436227-133505958 (-)
BALB/cJ MGP_BALBcJ_G0016394
 protein coding gene Chr1:129952542-130021767 (-)
C3H/HeJ MGP_C3HHeJ_G0016220
 protein coding gene Chr1:133573101-133642613 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016855
 protein coding gene Chr1:139598583-139675600 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014569
 protein coding gene Chr1:122761499-122828542 (-)
CAST/EiJ MGP_CASTEiJ_G0015800
 protein coding gene Chr1:132574683-132643295 (-)
CBA/J MGP_CBAJ_G0016192
 protein coding gene Chr1:144410110-144480556 (-)
DBA/2J MGP_DBA2J_G0016299
 protein coding gene Chr1:128590812-128659679 (-)
FVB/NJ MGP_FVBNJ_G0016298
 protein coding gene Chr1:127217021-127287713 (-)
LP/J MGP_LPJ_G0016370
 protein coding gene Chr1:135913496-135986333 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016323
 protein coding gene Chr1:150174067-150245034 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016891
 protein coding gene Chr1:133202541-133272391 (-)
PWK/PhJ MGP_PWKPhJ_G0015586
 protein coding gene Chr1:127546668-127615957 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015373
 protein coding gene Chr1:132131507-132199903 (-)
WSB/EiJ MGP_WSBEiJ_G0015862
 protein coding gene Chr1:133180518-133253274 (-)



Homology
more
  • Human Ortholog
    RASSF5, Ras association domain family member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RASSF5, Ras association domain family member 5
  • Synonyms
    Maxp1, NORE1, NORE1A, NORE1B, RAPL, RASSF3
  • Links
    NCBI Gene ID: 83593
    neXtProt AC: NX_Q8WWW0
    UniProt: Q8WWW0

  • Chr Location
    1q32.1; chr1:206507531-206589448 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rassf5 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele have defects in lymphocyte homing to lymphoid tissues, B cell maturation and dendritic cell function, and display lymphocyte hyperproliferation leading to lupus glomerulonephritis and lymphomas. Homozygotes for another null allele are resistant to TNF-induced apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    3
  • cDNA Data
    34
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54354 NCBI Gene Model | MGI Sequence Detail 68769 C57BL/6J ±  kb
    transcript NM_018750 RefSeq | MGI Sequence Detail 3410 ZRU/MplStud  
    polypeptide Q5EBH1 UniProt | EBI | MGI Sequence Detail 413 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 35
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1921412, MGI:2138497
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 13
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:313924 Sandoval M, et al., Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium. Elife. 2021 Jan 4;10:e54618
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory