Fzr1 MGI Mouse Gene Detail - MGI:1926790 - fizzy and cell division cycle 20 related 1

Symbol

Fzr1
Name

fizzy and cell division cycle 20 related 1
Synonyms

Cdh1, Fyr

Feature Type

protein coding gene
IDs

MGI:1926790
NCBI Gene: 56371
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:81202713-81214204 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

1 experiment

SNPs within 2kb

253 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926790	protein coding gene	Chr10:81202056-81214350 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017556	protein coding gene	Chr10:82078576-82091652 (-)
A/J	MGP_AJ_G0017534	protein coding gene	Chr10:79170034-79182690 (-)
AKR/J	MGP_AKRJ_G0017495	protein coding gene	Chr10:81344819-81357113 (-)
BALB/cJ	MGP_BALBcJ_G0017496	protein coding gene	Chr10:79389875-79402169 (-)
C3H/HeJ	MGP_C3HHeJ_G0017319	protein coding gene	Chr10:81445237-81457531 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017950	protein coding gene	Chr10:84897370-84909664 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015639	protein coding gene	Chr10:75369114-75380591 (-)
CAST/EiJ	MGP_CASTEiJ_G0016886	protein coding gene	Chr10:81677212-81689701 (-)
CBA/J	MGP_CBAJ_G0017291	protein coding gene	Chr10:88211597-88223891 (-)
DBA/2J	MGP_DBA2J_G0017397	protein coding gene	Chr10:78374526-78386820 (-)
FVB/NJ	MGP_FVBNJ_G0017391	protein coding gene	Chr10:77625570-77639090 (-)
LP/J	MGP_LPJ_G0017468	protein coding gene	Chr10:82527653-82539947 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017417	protein coding gene	Chr10:90052530-90065494 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017991	protein coding gene	Chr10:81354442-81366736 (-)
PWK/PhJ	MGP_PWKPhJ_G0016667	protein coding gene	Chr10:78268812-78281215 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016457	protein coding gene	Chr10:80302805-80315611 (-)
WSB/EiJ	MGP_WSBEiJ_G0016946	protein coding gene	Chr10:81389254-81401538 (-)

Human Ortholog

FZR1, fizzy and cell division cycle 20 related 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FZR1, fizzy and cell division cycle 20 related 1
Synonyms

CDC20C, CDH1, DEE109, FZR, FZR2, HCDH, HCDH1
Links

HGNC:24824

NCBI Gene ID: 51343

neXtProt AC: NX_Q9UM11

UniProt: Q9UM11
Chr Location

19p13.3; chr19:3506311-3538334 (+) GRCh38

MGI Vertebrate Homology

Fzr1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FZR1
Gene Tree

Fzr1

Diseases

1 with human FZR1 associations

				Human Disease	Mouse Models
				developmental and epileptic encephalopathy 109 IDs developmental and epileptic encephalopathy 109 DOID:0070378 OMIM:620145

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

37 phenotypes from 7 alleles in 7 genetic backgrounds
47 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

50
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

39
Targeted

8
Genomic Mutations

1 involving Fzr1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants die embryonically at around E9.5-E12.5 with poorly developed placentae, no placental giant cells and/or erythroblast deficiency. Homozygous MEFs undergo premature senescence. Heterozygotes exhibit learning/memory defects and/or elevatedspontaneous epithelial tumor incidence.

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All GO Annotations

30
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

885
Tissues

40
cDNA Data

13
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fzr1

ZFIN fzr1a

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All Sequences

66
RefSeq

2
UniProt

7
CCDS

CCDS24057.1

Ensembl

ENSMUSG00000020235 (Evidence)
NCBI Gene

56371

			Length	Strain/Species	Flank
genomic	56371	NCBI Gene Model \| MGI Sequence Detail	11492	C57BL/6J	± kb
transcript	NM_019757	RefSeq \| MGI Sequence Detail	2258	Not Specified
polypeptide	Q9R1K5	UniProt \| EBI \| MGI Sequence Detail	493	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000007725 fizzy-related protein

(term hierarchy)
InterPro Domains

IPR024977 Anaphase-promoting complex subunit 4-like, WD40 domain

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

IPR033010 WD repeat Cdc20/Fizzy

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All nucleic 14

cDNA 13

Primer pair 1

Microarray probesets 5

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MGI:2143808

Summaries

All 100

Developmental Gene Expression 10

Gene Ontology 12

Phenotypes 47
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fzr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98602	Chr10:81214662-81214678 (-)	-466 bp
Tssr98601	Chr10:81214293-81214316 (-)	-101 bp
Tssr98600	Chr10:81214232-81214290 (-)	-57 bp
Tssr98599	Chr10:81214214-81214225 (-)	-16 bp
Tssr3286	Chr10:81214188-81214195 (-)	12 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24