Ctdp1 MGI Mouse Gene Detail - MGI:1926953 - CTD phosphatase subunit 1

Symbol

Ctdp1
Name

CTD phosphatase subunit 1
Synonyms

4930563P03Rik

Feature Type

protein coding gene
IDs

MGI:1926953
NCBI Gene: 67655
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr18:80451174-80512910 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 53.48 cM
Mapping Data

3 experiments

SNPs within 2kb

1866 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926953	protein coding gene	Chr18:80451174-80522959 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024596	protein coding gene	Chr18:81339850-81402505 (-)
A/J	MGP_AJ_G0024563	protein coding gene	Chr18:77769610-77831622 (-)
AKR/J	MGP_AKRJ_G0024534	protein coding gene	Chr18:80100821-80162568 (-)
BALB/cJ	MGP_BALBcJ_G0024561	protein coding gene	Chr18:77952682-78014504 (-)
C3H/HeJ	MGP_C3HHeJ_G0024330	protein coding gene	Chr18:80183604-80245338 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025008	protein coding gene	Chr18:83419887-83482654 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022439	protein coding gene	Chr18:76625036-76686615 (-)
CAST/EiJ	MGP_CASTEiJ_G0023803	protein coding gene	Chr18:80520583-80583477 (-)
CBA/J	MGP_CBAJ_G0024300	protein coding gene	Chr18:86467603-86531017 (-)
DBA/2J	MGP_DBA2J_G0024430	protein coding gene	Chr18:77315140-77377061 (-)
FVB/NJ	MGP_FVBNJ_G0024396	protein coding gene	Chr18:76636374-76699875 (-)
LP/J	MGP_LPJ_G0024514	protein coding gene	Chr18:81200001-81262707 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024426	protein coding gene	Chr18:87719865-87781704 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025057	protein coding gene	Chr18:80239324-80302214 (-)
PWK/PhJ	MGP_PWKPhJ_G0023548	protein coding gene	Chr18:77720451-77782550 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023354	protein coding gene	Chr18:80424529-80487219 (-)
WSB/EiJ	MGP_WSBEiJ_G0023865	protein coding gene	Chr18:80192170-80255337 (-)

Human Ortholog

CTDP1, CTD phosphatase subunit 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTDP1, CTD phosphatase subunit 1
Synonyms

CCFDN, FCP1
Links

HGNC:2498

NCBI Gene ID: 9150

neXtProt AC: NX_Q9Y5B0

UniProt: Q9Y5B0
Chr Location

18q23; chr18:79676768-79756625 (+) GRCh38

MGI Vertebrate Homology

Ctdp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CTDP1
Gene Tree

Ctdp1

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Phenotype Summary

10 phenotypes from 3 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

4
Gene trapped

6
Targeted

3
Transposon induced

1
Genomic Mutations

1 involving Ctdp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit embryonic lethality with increased cell apoptosis.

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All GO Annotations

45
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

11
cDNA Data

53
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctdp1

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All Sequences

57
RefSeq

7
UniProt

4
CCDS

CCDS29368.1

Ensembl

ENSMUSG00000033323 (Evidence)
NCBI Gene

67655

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033323	Ensembl Gene Model \| MGI Sequence Detail	61737	C57BL/6J	± kb
transcript	ENSMUST00000036229	Ensembl \| MGI Sequence Detail	3713	Not Applicable
polypeptide	ENSMUSP00000038938	Ensembl \| MGI Sequence Detail	960	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005999 RNA polymerase II subunit A C-terminal domain phosphatase

(term hierarchy)
EC

3.1.3.16
InterPro Domains

IPR001357 BRCT domain

IPR036420 BRCT domain superfamily

IPR039189 CTD phosphatase Fcp1

IPR004274 FCP1 homology domain

IPR015388 FCP1-like phosphatase, C-terminal

IPR011947 FCP1-like phosphatase, phosphatase domain

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR011053 Single hybrid motif

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All nucleic 53

cDNA 53

Microarray probesets 3

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MGI:1914905, MGI:2147375

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ctdp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154029	Chr18:80512879-80512934 (-)	3 bp
Tssr154028	Chr18:80512873-80512877 (-)	35 bp
Tssr154027	Chr18:80512855-80512864 (-)	50 bp
Tssr154026	Chr18:80494463-80494474 (-)	18,441 bp
Tssr154025	Chr18:80484065-80484080 (-)	28,837 bp
Tssr154024	Chr18:80484021-80484050 (-)	28,874 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24