Cables1 MGI Mouse Gene Detail - MGI:1927065 - CDK5 and Abl enzyme substrate 1

Symbol

Cables1
Name

CDK5 and Abl enzyme substrate 1
Synonyms

ik3-1, interactor-1 with cdk3

Feature Type

protein coding gene
IDs

MGI:1927065
NCBI Gene: 63955
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr18:11972600-12078681 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 5.88 cM, cytoband A2
Mapping Data

1 experiment

SNPs within 2kb

3460 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927065	protein coding gene	Chr18:11972277-12078687 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024154	protein coding gene	Chr18:8968529-9083868 (+)
A/J	MGP_AJ_G0024116	protein coding gene	Chr18:8840843-8946905 (+)
AKR/J	MGP_AKRJ_G0024083	protein coding gene	Chr18:9097404-9202969 (+)
BALB/cJ	MGP_BALBcJ_G0024115	protein coding gene	Chr18:8785079-8890178 (+)
C3H/HeJ	MGP_C3HHeJ_G0023882	protein coding gene	Chr18:8979688-9092945 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024560	protein coding gene	Chr18:9455774-9564721 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021999	protein coding gene	Chr18:8438952-8548195 (+)
CAST/EiJ	MGP_CASTEiJ_G0023359	protein coding gene	Chr18:8842259-8986722 (+)
CBA/J	MGP_CBAJ_G0023854	protein coding gene	Chr18:9578245-9690186 (+)
DBA/2J	MGP_DBA2J_G0023983	protein coding gene	Chr18:8684640-8791122 (+)
FVB/NJ	MGP_FVBNJ_G0023948	protein coding gene	Chr18:8545160-8652874 (+)
LP/J	MGP_LPJ_G0024066	protein coding gene	Chr18:9067569-9180520 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023977	protein coding gene	Chr18:9761770-9878324 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024606	protein coding gene	Chr18:8874190-8985268 (+)
PWK/PhJ	MGP_PWKPhJ_G0023105	protein coding gene	Chr18:8746477-8887936 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022914	protein coding gene	Chr18:9130381-9268484 (+)
WSB/EiJ	MGP_WSBEiJ_G0023425	protein coding gene	Chr18:8872763-8983594 (+)

Human Ortholog

CABLES1, Cdk5 and Abl enzyme substrate 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CABLES1, Cdk5 and Abl enzyme substrate 1
Synonyms

CABL1, CABLES, HsT2563, IK3-1
Links

HGNC:25097

NCBI Gene ID: 91768

neXtProt AC: NX_Q8TDN4

UniProt: Q8TDN4
Chr Location

18q11.2; chr18:23134564-23260470 (+) GRCh38

MGI Vertebrate Homology

Cables1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CABLES1
Protein SuperFamily

Cables
Gene Tree

Cables1

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

2
Gene trapped

5
Targeted

6
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null females exhibited reduced fertility and uterine hyperplasia. With chronic exposure to estrogen, homozygous females develop endometrial adenocarcinoma.

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All GO Annotations

10
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

797
Tissues

66
cDNA Data

28
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cables1

ZFIN cables1

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All Sequences

50
RefSeq

4
UniProt

4
CCDS

CCDS29061.1, CCDS50220.1

Ensembl

ENSMUSG00000040957 (Evidence)
NCBI Gene

63955

			Length	Strain/Species	Flank
genomic	63955	NCBI Gene Model \| MGI Sequence Detail	106082	C57BL/6J	± kb
transcript	NM_001146287	RefSeq \| MGI Sequence Detail	3071	C57BL/6
polypeptide	Q9ESJ1	UniProt \| EBI \| MGI Sequence Detail	568	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004931 CDK5 and ABL1 enzyme substrate 1

(term hierarchy)
InterPro Domains

IPR012388 CDK5 and ABL1 enzyme substrate 1/2

IPR036915 Cyclin-like superfamily

IPR006671 Cyclin, N-terminal
GlyGen

Q9ESJ1 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 29

cDNA 28

Other 1

Microarray probesets 5

Summaries

All 41

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 13
Earliest

J:63117 Zukerberg LR, et al., Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. Neuron. 2000 Jun;26(3):633-46
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Cables1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150074	Chr18:11972473-11972532 (+)	-97 bp
Tssr150075	Chr18:11972552-11972576 (+)	-36 bp
Tssr150076	Chr18:11972593-11972608 (+)	1 bp
Tssr150077	Chr18:12051116-12051120 (+)	78,518 bp
Tssr150078	Chr18:12058012-12058016 (+)	85,414 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24