Dmrtb1 MGI Mouse Gene Detail - MGI:1927125 - DMRT-like family B with proline-rich C-terminal, 1

Symbol

Dmrtb1
Name

DMRT-like family B with proline-rich C-terminal, 1
Synonyms

Dmrt6, Prp13

Feature Type

protein coding gene
IDs

MGI:1927125
NCBI Gene: 56296
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr4:107533487-107541427 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 50.18 cM, cytoband C7
Mapping Data

1 experiment

SNPs within 2kb

268 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927125	protein coding gene	Chr4:107533485-107561208 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028541	protein coding gene	Chr4:108357107-108367418 (-)
A/J	MGP_AJ_G0028504	protein coding gene	Chr4:104479609-104487473 (-)
AKR/J	MGP_AKRJ_G0028451	protein coding gene	Chr4:107047517-107057300 (-)
BALB/cJ	MGP_BALBcJ_G0028523	protein coding gene	Chr4:104666303-104676120 (-)
C3H/HeJ	MGP_C3HHeJ_G0028237	protein coding gene	Chr4:107785795-107793621 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028963	protein coding gene	Chr4:112251710-112261301 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026254	protein coding gene	Chr4:99754204-99761859 (-)
CAST/EiJ	MGP_CASTEiJ_G0027673	protein coding gene	Chr4:105612400-105624298 (-)
CBA/J	MGP_CBAJ_G0028206	protein coding gene	Chr4:115896255-115906010 (-)
DBA/2J	MGP_DBA2J_G0028354	protein coding gene	Chr4:104102248-104110281 (-)
FVB/NJ	MGP_FVBNJ_G0028322	protein coding gene	Chr4:102966105-102975651 (-)
LP/J	MGP_LPJ_G0028455	protein coding gene	Chr4:108565061-108574425 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028348	protein coding gene	Chr4:121160579-121169390 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028999	protein coding gene	Chr4:107284260-107292126 (-)
PWK/PhJ	MGP_PWKPhJ_G0027399	protein coding gene	Chr4:102344890-102351337 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027223	protein coding gene	Chr4:104656945-104664583 (-)
WSB/EiJ	MGP_WSBEiJ_G0027754	protein coding gene	Chr4:107463669-107473468 (-)

Human Ortholog

DMRTB1, DMRT like family B with proline rich C-terminal 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DMRTB1, DMRT like family B with proline rich C-terminal 1
Links

HGNC:13913

NCBI Gene ID: 63948

neXtProt AC: NX_Q96MA1

UniProt: Q96MA1
Chr Location

1p32.3; chr1:53459399-53467488 (+) GRCh38

MGI Vertebrate Homology

Dmrtb1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DMRTB1
Gene Tree

Dmrtb1

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Phenotype Summary

10 phenotypes from 1 allele in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

6
Radiation induced

1
Targeted

3
Genomic Mutations

4 involving Dmrtb1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a knock-out allele exhibit severe spermatogenesis defects, including a disruption of spermatogonial differentiation and a failure to complete meiotic prophase.

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

26
cDNA Data

34
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dmrtb1

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All Sequences

49
RefSeq

12
UniProt

5
CCDS

CCDS51254.1

Ensembl

ENSMUSG00000028610 (Evidence)
NCBI Gene

56296

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028610	Ensembl Gene Model \| MGI Sequence Detail	7941	C57BL/6J	± kb
transcript	ENSMUST00000069271	Ensembl \| MGI Sequence Detail	1861	Not Applicable
polypeptide	ENSMUSP00000064220	Ensembl \| MGI Sequence Detail	359	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000006547 doublesex- and mab-3-related transcription factor B1

(term hierarchy)
InterPro Domains

IPR001275 DM DNA-binding domain

IPR036407 DM DNA-binding domain superfamily

IPR026607 DMRT family

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All nucleic 38

Genomic 2

cDNA 34

Primer pair 2

Microarray probesets 3

Summaries

All 41

Developmental Gene Expression 7

Gene Ontology 6

Phenotypes 10
Earliest

J:44866 Ermekova KS, et al., The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. J Biol Chem. 1997 Dec 26;272(52):32869-77
Latest

J:342617 Dali O, et al., Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure. Life Sci Alliance. 2024 Feb;7(2)

TSS for Dmrtb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr42693	Chr4:107541425-107541428 (-)	0 bp
Tssr42692	Chr4:107540773-107540789 (-)	646 bp
Tssr42691	Chr4:107540727-107540771 (-)	678 bp
Tssr42690	Chr4:107538155-107538182 (-)	3,258 bp
Tssr42689	Chr4:107538100-107538139 (-)	3,307 bp
Tssr42688	Chr4:107538072-107538084 (-)	3,349 bp
Tssr42687	Chr4:107538047-107538068 (-)	3,369 bp
Tssr42686	Chr4:107537968-107538044 (-)	3,421 bp
Tssr42685	Chr4:107537938-107537967 (-)	3,474 bp
Tssr42684	Chr4:107536577-107536592 (-)	4,842 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24