Gmfb MGI Mouse Gene Detail - MGI:1927133 - glia maturation factor, beta

Symbol

Gmfb
Name

glia maturation factor, beta
Synonyms

3110001H22Rik, 3110001O16Rik, D14Ertd630e

Feature Type

protein coding gene
IDs

MGI:1927133
NCBI Gene: 63985
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr14:47045606-47059699 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 24.32 cM
Mapping Data

3 experiments

SNPs within 2kb

405 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927133	protein coding gene	Chr14:47045606-47059711 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021215	protein coding gene	Chr14:40496350-40510198 (-)
A/J	MGP_AJ_G0021162	protein coding gene	Chr14:39288239-39302089 (-)
AKR/J	MGP_AKRJ_G0021140	protein coding gene	Chr14:40813652-40827498 (-)
BALB/cJ	MGP_BALBcJ_G0021166	protein coding gene	Chr14:39333279-39347129 (-)
C3H/HeJ	MGP_C3HHeJ_G0020949	protein coding gene	Chr14:40599536-40613386 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021600	protein coding gene	Chr14:42246481-42260534 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019159	protein coding gene	Chr14:38653939-38667832 (-)
CAST/EiJ	MGP_CASTEiJ_G0020474	protein coding gene	Chr14:37728242-37742137 (-)
CBA/J	MGP_CBAJ_G0020915	protein coding gene	Chr14:43584123-43597973 (-)
DBA/2J	MGP_DBA2J_G0021038	protein coding gene	Chr14:39186191-39200042 (-)
FVB/NJ	MGP_FVBNJ_G0021023	protein coding gene	Chr14:38920385-38934272 (-)
LP/J	MGP_LPJ_G0021108	protein coding gene	Chr14:40788543-40802486 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021048	protein coding gene	Chr14:42950418-42964286 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021633	protein coding gene	Chr14:40356897-40370760 (-)
PWK/PhJ	MGP_PWKPhJ_G0020223	protein coding gene	Chr14:36062650-36077007 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020047	protein coding gene	Chr14:36489639-36503457 (-)
WSB/EiJ	MGP_WSBEiJ_G0020530	protein coding gene	Chr14:40459776-40477512 (-)

Human Ortholog

GMFB, glia maturation factor beta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GMFB, glia maturation factor beta
Synonyms

GMF
Links

HGNC:4373

NCBI Gene ID: 2764

neXtProt AC: NX_P60983

UniProt: P60983
Chr Location

14q22.2; chr14:54474484-54489025 (-) GRCh38

MGI Vertebrate Homology

Gmfb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GMFB
Protein SuperFamily

GMF-beta
Gene Tree

Gmfb

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

5
Targeted

3
Genomic Mutations

1 involving Gmfb
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display impaired balance and eye blink conditioning behavior and abnormal metencephalon morphology.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

772
Tissues

42
cDNA Data

264
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gmfb

ZFIN gmfb

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All Sequences

70
RefSeq

14
UniProt

5
CCDS

CCDS36898.1

Ensembl

ENSMUSG00000062014 (Evidence)
NCBI Gene

63985

			Length	Strain/Species	Flank
genomic	ENSMUSG00000062014	Ensembl Gene Model \| MGI Sequence Detail	14094	C57BL/6J	± kb
transcript	ENSMUST00000226333	Ensembl \| MGI Sequence Detail	739	Not Applicable
polypeptide	ENSMUSP00000153896	Ensembl \| MGI Sequence Detail	155	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008070 glia maturation factor beta

(term hierarchy)
PDB

1V6F
InterPro Domains

IPR002108 Actin-depolymerising factor homology domain

IPR029006 ADF-H/Gelsolin-like domain superfamily

IPR011171 Glia maturation factor

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All nucleic 269

cDNA 266

Primer pair 3

Microarray probesets 9

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MGI:1277226, MGI:1917674, MGI:1919071, MGI:2145701, MGI:2145860

Summaries

All 54

Developmental Gene Expression 7

Gene Ontology 5

Phenotypes 19
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:313930 Tan L, et al., Overexpression of Long Non-coding RNA 4933425B07Rik Causes Urinary Malformations in Mice. Front Cell Dev Biol. 2021;9:594640

TSS for Gmfb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128299	Chr14:47059689-47059723 (-)	-7 bp
Tssr128298	Chr14:47059628-47059679 (-)	45 bp
Tssr128297	Chr14:47059593-47059624 (-)	90 bp
Tssr128296	Chr14:47059579-47059592 (-)	113 bp
Tssr128295	Chr14:47059487-47059518 (-)	196 bp
Tssr128294	Chr14:47059389-47059432 (-)	288 bp
Tssr128293	Chr14:47046730-47046742 (-)	12,963 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24