Chp1 MGI Mouse Gene Detail - MGI:1927185 - calcineurin-like EF hand protein 1

Symbol

Chp1
Name

calcineurin-like EF hand protein 1
Synonyms

1500003O03Rik, Sid470p, vac

Feature Type

protein coding gene
IDs

MGI:1927185
NCBI Gene: 56398
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:119378178-119417508 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 59.97 cM
Mapping Data

3 experiments

SNPs within 2kb

865 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927185	protein coding gene	Chr2:119378172-119417508 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026345	protein coding gene	Chr2:122319175-122375120 (+)
A/J	MGP_AJ_G0026306	protein coding gene	Chr2:117345645-117386079 (+)
AKR/J	MGP_AKRJ_G0026285	protein coding gene	Chr2:120619711-120660058 (+)
BALB/cJ	MGP_BALBcJ_G0026319	protein coding gene	Chr2:117591666-117632408 (+)
C3H/HeJ	MGP_C3HHeJ_G0026065	protein coding gene	Chr2:121085155-121128881 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026766	protein coding gene	Chr2:126333859-126382199 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024146	protein coding gene	Chr2:112382848-112420309 (+)
CAST/EiJ	MGP_CASTEiJ_G0025527	protein coding gene	Chr2:121403059-121444271 (+)
CBA/J	MGP_CBAJ_G0026041	protein coding gene	Chr2:130784900-130829082 (+)
DBA/2J	MGP_DBA2J_G0026180	protein coding gene	Chr2:116749554-116789873 (+)
FVB/NJ	MGP_FVBNJ_G0026142	protein coding gene	Chr2:115572892-115613042 (+)
LP/J	MGP_LPJ_G0026281	protein coding gene	Chr2:122622857-122663192 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026161	protein coding gene	Chr2:135108194-135152429 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026821	protein coding gene	Chr2:120735987-120780924 (+)
PWK/PhJ	MGP_PWKPhJ_G0025263	protein coding gene	Chr2:116328063-116370396 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025062	protein coding gene	Chr2:119928701-119967031 (+)
WSB/EiJ	MGP_WSBEiJ_G0025596	protein coding gene	Chr2:121575983-121618595 (+)

Human Ortholog

CHP1, calcineurin like EF-hand protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CHP1, calcineurin like EF-hand protein 1
Synonyms

CHP, p22, p24, Sid470p, SLC9A1BP, SPAX9
Links

HGNC:17433

NCBI Gene ID: 11261

neXtProt AC: NX_Q99653

UniProt: Q99653
Chr Location

15q15.1; chr15:41230839-41281887 (+) GRCh38

MGI Vertebrate Homology

Chp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CHP1
Gene Tree

Chp1

Diseases

1 with human CHP1 associations

				Human Disease	Mouse Models
				spastic ataxia IDs spastic ataxia DOID:0050952 MESH:C564815

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

4
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Chp1
Incidental Mutations

APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU mutation display ataxia and progressive Purkinje cell axonal dystrophy.

less

All GO Annotations

83
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

15
cDNA Data

324
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase chp1

ZFIN chp1

less

All Sequences

58
RefSeq

4
UniProt

3
CCDS

CCDS16604.1

Ensembl

ENSMUSG00000014077 (Evidence)
NCBI Gene

56398

			Length	Strain/Species	Flank
genomic	ENSMUSG00000014077	Ensembl Gene Model \| MGI Sequence Detail	39331	C57BL/6J	± kb
transcript	ENSMUST00000014221	Ensembl \| MGI Sequence Detail	2609	Not Applicable
polypeptide	ENSMUSP00000014221	Ensembl \| MGI Sequence Detail	195	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000005446 calcineurin B homologous protein 1

(term hierarchy)
InterPro Domains

IPR051875 Calcineurin B homologous

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair
GlyGen

P61022 1 site, 1 N-linked glycan (1 site)

less

All nucleic 324

cDNA 324

Microarray probesets 6

less

MGI:1915310, MGI:2146369, MGI:2146375, MGI:5438383

Summaries

All 47

Developmental Gene Expression 1

Gene Ontology 10

Phenotypes 13
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Chp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19637	Chr2:119378156-119378170 (+)	-15 bp
Tssr19638	Chr2:119378182-119378243 (+)	35 bp
Tssr19639	Chr2:119378246-119378283 (+)	87 bp
Tssr19640	Chr2:119378284-119378297 (+)	113 bp
Tssr19641	Chr2:119415046-119415065 (+)	36,878 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24