Gosr2 MGI Mouse Gene Detail - MGI:1927204 - golgi SNAP receptor complex member 2

Symbol

Gosr2
Name

golgi SNAP receptor complex member 2
Synonyms

2310032N09Rik, GS27, membrin, SNARE

Feature Type

protein coding gene
IDs

MGI:1927204
NCBI Gene: 56494
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:103567675-103588724 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 67.43 cM
Mapping Data

2 experiments

SNPs within 2kb

659 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927204	protein coding gene	Chr11:103567675-103590139 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019267	protein coding gene	Chr11:106780114-106800939 (-)
A/J	MGP_AJ_G0019235	protein coding gene	Chr11:102236669-102259786 (-)
AKR/J	MGP_AKRJ_G0019204	protein coding gene	Chr11:105382519-105403660 (-)
BALB/cJ	MGP_BALBcJ_G0019209	protein coding gene	Chr11:102678203-102699350 (-)
C3H/HeJ	MGP_C3HHeJ_G0019018	protein coding gene	Chr11:105608375-105632924 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019659	protein coding gene	Chr11:110086310-110109960 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017284	protein coding gene	Chr11:99650460-99671671 (-)
CAST/EiJ	MGP_CASTEiJ_G0018572	protein coding gene	Chr11:106630830-106651644 (-)
CBA/J	MGP_CBAJ_G0018987	protein coding gene	Chr11:114647810-114668709 (-)
DBA/2J	MGP_DBA2J_G0019099	protein coding gene	Chr11:101736627-101757942 (-)
FVB/NJ	MGP_FVBNJ_G0019090	protein coding gene	Chr11:101257713-101280249 (-)
LP/J	MGP_LPJ_G0019168	protein coding gene	Chr11:107264465-107288269 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019120	protein coding gene	Chr11:113993818-114016080 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019696	protein coding gene	Chr11:105767264-105787600 (-)
PWK/PhJ	MGP_PWKPhJ_G0018336	protein coding gene	Chr11:102816499-102837832 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018127	protein coding gene	Chr11:105515489-105540205 (-)
WSB/EiJ	MGP_WSBEiJ_G0018621	protein coding gene	Chr11:105770482-105792634 (-)

Human Ortholog

GOSR2, golgi SNAP receptor complex member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GOSR2, golgi SNAP receptor complex member 2
Synonyms

Bos1, EPM6, GS27, MYOS
Links

HGNC:4431

NCBI Gene ID: 9570

neXtProt AC: NX_O14653

UniProt: O14653
Chr Location

17q21.32; chr17:46923075-46975890 (+) GRCh38

MGI Vertebrate Homology

Gosr2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GOSR2
Protein SuperFamily

Membrin-2
Gene Tree

Gosr2

Diseases

1 with human GOSR2 associations

				Human Disease	Mouse Models
				progressive myoclonus epilepsy 6 IDs progressive myoclonus epilepsy 6 DOID:0111449 OMIM:614018 ORDO:280620

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

1
Gene trapped

13
Targeted

4
Genomic Mutations

1 involving Gosr2
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

25
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

33
cDNA Data

192
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gosr2

ZFIN gosr2

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All Sequences

72
RefSeq

25
UniProt

2
CCDS

CCDS25521.1, CCDS88267.1

Ensembl

ENSMUSG00000020946 (Evidence)
NCBI Gene

56494

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020946	Ensembl Gene Model \| MGI Sequence Detail	21050	C57BL/6J	± kb
transcript	ENSMUST00000021329	Ensembl \| MGI Sequence Detail	3266	Not Applicable
polypeptide	ENSMUSP00000021329	Ensembl \| MGI Sequence Detail	212	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008152 Golgi SNAP receptor complex member 2

(term hierarchy)
InterPro Domains

IPR027027 GOSR2/Membrin/Bos1

IPR038407 Vesicle transport v-SNARE, N-terminal domain superfamily

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All nucleic 193

cDNA 192

Primer pair 1

Microarray probesets 6

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MGI:1913639, MGI:2144622

Summaries

All 49

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 15
Earliest

J:46012 Hay JC, et al., Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Cell. 1997 Apr 4;89(1):149-58
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gosr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111219	Chr11:103588862-103588871 (-)	-143 bp
Tssr111218	Chr11:103588763-103588774 (-)	-45 bp
Tssr111217	Chr11:103588605-103588616 (-)	113 bp
Tssr111216	Chr11:103588549-103588560 (-)	169 bp
Tssr111215	Chr11:103588487-103588544 (-)	208 bp
Tssr111214	Chr11:103587887-103587889 (-)	836 bp
Tssr111213	Chr11:103583271-103583279 (-)	5,449 bp
Tssr111212	Chr11:103577663-103577674 (-)	11,055 bp
Tssr111211	Chr11:103577586-103577596 (-)	11,133 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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