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Sv2b Gene Detail
Summary
  • Symbol
    Sv2b
  • Name
    synaptic vesicle glycoprotein 2b
  • Synonyms
    A830038F04Rik, mKIAA0735
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927338
    NCBI Gene: 64176
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:74764642-74959010 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 43.62 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6232 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927338
 protein coding gene Chr7:74764642-74959143 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032373
 protein coding gene Chr7:76762974-76968160 (-)
A/J MGP_AJ_G0032352
 protein coding gene Chr7:75022799-75203719 (-)
AKR/J MGP_AKRJ_G0032288
 protein coding gene Chr7:76623274-76814020 (-)
BALB/cJ MGP_BALBcJ_G0032364
 protein coding gene Chr7:74781333-74974318 (-)
C3H/HeJ MGP_C3HHeJ_G0032077
 protein coding gene Chr7:77334101-77517829 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032856
 protein coding gene Chr7:79923512-80119489 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029864
 protein coding gene Chr7:77868563-78048573 (-)
CAST/EiJ MGP_CASTEiJ_G0031405
 protein coding gene Chr7:68223119-68410753 (-)
CBA/J MGP_CBAJ_G0032043
 protein coding gene Chr7:82468091-82669705 (-)
DBA/2J MGP_DBA2J_G0032198
 protein coding gene Chr7:73669864-73859907 (-)
FVB/NJ MGP_FVBNJ_G0032153
 protein coding gene Chr7:73667230-73870211 (-)
LP/J MGP_LPJ_G0032279
 protein coding gene Chr7:78008700-78214451 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032190
 protein coding gene Chr7:82616099-82827393 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032874
 protein coding gene Chr7:76083519-76281187 (-)
PWK/PhJ MGP_PWKPhJ_G0031125
 protein coding gene Chr7:66859579-67039821 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030966
 protein coding gene Chr7:63170832-63375372 (-)
WSB/EiJ MGP_WSBEiJ_G0031523
 protein coding gene Chr7:76429034-76632611 (-)



Homology
more
  • Human Ortholog
    SV2B, synaptic vesicle glycoprotein 2B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SV2B, synaptic vesicle glycoprotein 2B
  • Synonyms
    HsT19680, SLC22B2
  • Links
    NCBI Gene ID: 9899
    neXtProt AC: NX_Q7L1I2
    UniProt: Q7L1I2

  • Chr Location
    15q26.1; chr15:91099588-91302565 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation are phenotypically normal, and Sv2a/Sv2b double knockouts are no more affected than Sv2a single knockouts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1173
  • Tissues
    185
  • cDNA Data
    38
  • Literature Summary
    34
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053025 Ensembl Gene Model | MGI Sequence Detail 194369 C57BL/6J ±  kb
    transcript ENSMUST00000206344 Ensembl | MGI Sequence Detail 3910 Not Applicable  
    polypeptide ENSMUSP00000146049 Ensembl | MGI Sequence Detail 683 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000015850 synaptic vesicle glycoprotein 2B
      (term hierarchy)
    • InterPro Domains
      IPR005828 Major facilitator, sugar transporter-like
      IPR011701 Major facilitator superfamily
      IPR020846 Major facilitator superfamily domain
      IPR036259 MFS transporter superfamily
      IPR005829 Sugar transporter, conserved site
      IPR022308 Synaptic vesicle protein SV2
    • GlyGen
      Q8BG39 4 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 39
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142055, MGI:2443605
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 34
      Gene Ontology 7
      Phenotypes 30
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:342492 Bolz S, et al., Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis. Neuron. 2023 Sep 14;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory