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Pals1 Gene Detail
Summary
  • Symbol
    Pals1
  • Name
    protein associated with LIN7 1, MAGUK family member
  • Synonyms
    3830420B02Rik, Mpp5, Pals1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927339
    NCBI Gene: 56217
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:78795681-78887488 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 35.51 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1714 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927339
 protein coding gene Chr12:78795606-78887488 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019872
 protein coding gene Chr12:79013579-79115804 (+)
A/J MGP_AJ_G0019830
 protein coding gene Chr12:76178701-76265114 (+)
AKR/J MGP_AKRJ_G0019805
 protein coding gene Chr12:78244024-78337320 (+)
BALB/cJ MGP_BALBcJ_G0019809
 protein coding gene Chr12:76430256-76521256 (+)
C3H/HeJ MGP_C3HHeJ_G0019615
 protein coding gene Chr12:78706492-78802421 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020261
 protein coding gene Chr12:81351643-81445959 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017879
 protein coding gene Chr12:73207028-73291042 (+)
CAST/EiJ MGP_CASTEiJ_G0019165
 protein coding gene Chr12:73536316-73632940 (+)
CBA/J MGP_CBAJ_G0019585
 protein coding gene Chr12:84520873-84615756 (+)
DBA/2J MGP_DBA2J_G0019701
 protein coding gene Chr12:75801660-75889810 (+)
FVB/NJ MGP_FVBNJ_G0019687
 protein coding gene Chr12:74615350-74704772 (+)
LP/J MGP_LPJ_G0019773
 protein coding gene Chr12:78942680-79040517 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019726
 protein coding gene Chr12:87566322-87675359 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020297
 protein coding gene Chr12:77755717-77849642 (+)
PWK/PhJ MGP_PWKPhJ_G0018931
 protein coding gene Chr12:70137251-70228441 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018725
 protein coding gene Chr12:72258575-72344482 (+)
WSB/EiJ MGP_WSBEiJ_G0019218
 protein coding gene Chr12:78357857-78450411 (+)



Homology
more
  • Human Ortholog
    PALS1, protein associated with LIN7 1, MAGUK p55 family member
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PALS1, protein associated with LIN7 1, MAGUK p55 family member
  • Synonyms
    MPP5
  • Links
    NCBI Gene ID: 64398
    neXtProt AC: NX_Q8N3R9
    UniProt: Q8N3R9

  • Chr Location
    14q23.3; chr14:67240713-67336061 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pals1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    66 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a floxed allele activated in cortical neuron exhibit loss of cortex neurons due to premature differentiation and increased apoptosis. These mice also exhibit behavioral defects but are otherwise viable and fertile. Heterozygous mice exhibit an intermediate phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    37
  • cDNA Data
    14
  • Literature Summary
    35
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021112 Ensembl Gene Model | MGI Sequence Detail 91808 C57BL/6J ±  kb
    transcript ENSMUST00000082024 Ensembl | MGI Sequence Detail 5470 Not Applicable  
    polypeptide ENSMUSP00000080683 Ensembl | MGI Sequence Detail 675 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1917953, MGI:2144774, MGI:2144871, MGI:6515785
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 35
      Diseases 1
      Gene Ontology 19
      Phenotypes 21
    • Earliest
      J:64820 Kamberov E, et al., Molecular cloning and characterization of Pals, proteins associated with mLin-7. J Biol Chem. 2000 Apr 14;275(15):11425-31
    • Latest
      J:337476 Gredler ML, et al., Multicellular rosettes link mesenchymal-epithelial transition to radial intercalation in the mouse axial mesoderm. Dev Cell. 2023 Jun 5;58(11):933-950.e5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory