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Xrcc2 Gene Detail
Summary
  • Symbol
    Xrcc2
  • Name
    X-ray repair complementing defective repair in Chinese hamster cells 2
  • Synonyms
    4921524O04Rik, 8030409M04Rik, RecA
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927345
    NCBI Gene: 57434
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:25894812-25910795 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 12.35 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    572 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927345
 protein coding gene Chr5:25894810-25910823 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029363
 protein coding gene Chr5:23515315-23532671 (-)
A/J MGP_AJ_G0029329
 protein coding gene Chr5:22675999-22691955 (-)
AKR/J MGP_AKRJ_G0029280
 protein coding gene Chr5:23613397-23632440 (-)
BALB/cJ MGP_BALBcJ_G0029340
 protein coding gene Chr5:23188157-23204090 (-)
C3H/HeJ MGP_C3HHeJ_G0029060
 protein coding gene Chr5:23707810-23724699 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029793
 protein coding gene Chr5:25045623-25061700 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027031
 protein coding gene Chr5:20589069-20605040 (-)
CAST/EiJ MGP_CASTEiJ_G0028472
 protein coding gene Chr5:22914041-22931145 (-)
CBA/J MGP_CBAJ_G0029027
 protein coding gene Chr5:25504121-25520119 (-)
DBA/2J MGP_DBA2J_G0029178
 protein coding gene Chr5:22945365-22961602 (-)
FVB/NJ MGP_FVBNJ_G0029136
 protein coding gene Chr5:22330004-22346129 (-)
LP/J MGP_LPJ_G0029262
 protein coding gene Chr5:23908718-23926201 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029165
 protein coding gene Chr5:26558886-26575501 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029827
 protein coding gene Chr5:23223451-23239473 (-)
PWK/PhJ MGP_PWKPhJ_G0028196
 protein coding gene Chr5:22072547-22089049 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028027
 protein coding gene Chr5:22582421-22598213 (-)
WSB/EiJ MGP_WSBEiJ_G0028552
 protein coding gene Chr5:23306657-23326033 (-)



Homology
more
  • Human Ortholog
    XRCC2, X-ray repair cross complementing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    XRCC2, X-ray repair cross complementing 2
  • Synonyms
    FANCU, POF17, SPGF50
  • Links
    NCBI Gene ID: 7516
    neXtProt AC: NX_O43543
    UniProt: O43543

  • Chr Location
    7q36.1; chr7:152644776-152676193 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human XRCC2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit chromosomal instability, excess neuronal apoptosis, and lethality ranging from midgestation through birth. Neonates die from respiratory failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    1
  • cDNA Data
    34
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57434 NCBI Gene Model | MGI Sequence Detail 15984 C57BL/6J ±  kb
    transcript NM_020570 RefSeq | MGI Sequence Detail 3230 Not Specified  
    polypeptide Q9CX47 UniProt | EBI | MGI Sequence Detail 278 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000017505 DNA repair protein XRCC2
      (term hierarchy)
    • InterPro Domains
      IPR013632 DNA recombination and repair protein Rad51-like, C-terminal
      IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
      IPR030547 DNA repair protein XRCC2
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 36
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1918160, MGI:1925986
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 10
      Phenotypes 27
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:280228 Yang Y, et al., XRCC2 mutation causes meiotic arrest, azoospermia and infertility. J Med Genet. 2018 Sep;55(9):628-636
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory