Zbp1 MGI Mouse Gene Detail - MGI:1927449

Symbol

Zbp1
Name

Z-DNA binding protein 1
Synonyms

2010010H03Rik, Dai, mZaDLM

Feature Type

protein coding gene
IDs

MGI:1927449
NCBI Gene: 58203
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr2:173048405-173060715 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 95.83 cM, cytoband H3
Mapping Data

2 experiments

SNPs within 2kb

515 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927449	protein coding gene	Chr2:173048405-173060716 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026955	protein coding gene	Chr2:179466959-179478913 (-)
A/J	MGP_AJ_G0026922	protein coding gene	Chr2:171919706-171931650 (-)
AKR/J	MGP_AKRJ_G0026893	protein coding gene	Chr2:177104746-177116705 (-)
BALB/cJ	MGP_BALBcJ_G0026931	protein coding gene	Chr2:172321120-172333450 (-)
C3H/HeJ	MGP_C3HHeJ_G0026673	protein coding gene	Chr2:177494487-177506799 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027378	protein coding gene	Chr2:184627896-184644329 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024748	protein coding gene	Chr2:165155662-165167912 (-)
CAST/EiJ	MGP_CASTEiJ_G0026131	protein coding gene	Chr2:178187214-178199200 (-)
CBA/J	MGP_CBAJ_G0026650	protein coding gene	Chr2:191535387-191547803 (-)
DBA/2J	MGP_DBA2J_G0026788	protein coding gene	Chr2:171012385-171024710 (-)
FVB/NJ	MGP_FVBNJ_G0026754	protein coding gene	Chr2:169632795-169645388 (-)
LP/J	MGP_LPJ_G0026889	protein coding gene	Chr2:179397892-179411222 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026773	protein coding gene	Chr2:194467402-194479715 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027435	protein coding gene	Chr2:177124708-177139114 (-)
PWK/PhJ	MGP_PWKPhJ_G0025868	protein coding gene	Chr2:170808260-170821022 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025668	protein coding gene	Chr2:176128279-176140084 (-)
WSB/EiJ	MGP_WSBEiJ_G0026204	protein coding gene	Chr2:178071702-178085332 (-)

Human Ortholog

ZBP1, Z-DNA binding protein 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZBP1, Z-DNA binding protein 1
Synonyms

C20orf183, DAI, DLM-1, DLM1
Links

HGNC:16176

NCBI Gene ID: 81030

neXtProt AC: NX_Q9H171

UniProt: Q9H171
Chr Location

20q13.31; chr20:57603846-57620576 (-) GRCh38

MGI Vertebrate Homology

Zbp1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ZBP1
Gene Tree

Zbp1

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Endonuclease-mediated

10
Gene trapped

6
Targeted

6
Incidental Mutations

APF
Find Mice (IMSR)

29 strains or lines available

Mice homozygous for a knock-out allele display normal innate immune activation by double-stranded B-form DNA (B-DNA) as well as normal adaptive immune responses to DNA vaccination.

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All GO Annotations

35
GO References

22

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

6
cDNA Data

36
Literature Summary

6

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

4
UniProt

2
CCDS

CCDS17142.1, CCDS50813.1

Ensembl

ENSMUSG00000027514 (Evidence)
NCBI Gene

58203

			Length	Strain/Species	Flank
genomic	58203	NCBI Gene Model \| MGI Sequence Detail	12311	C57BL/6J	± kb
transcript	NM_021394	RefSeq \| MGI Sequence Detail	1988	C57BL/6
polypeptide	Q9QY24	UniProt \| EBI \| MGI Sequence Detail	411	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017560 Z-DNA-binding protein 1

(term hierarchy)
PDB

1J75, 2HEO
InterPro Domains

IPR025735 RHIM domain

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

IPR042371 Z-binding domain

IPR042361 Z-DNA-binding protein 1
GlyGen

Q9QY24 1 site, 1 O-linked glycan (1 site)

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All nucleic 36

cDNA 36

Microarray probesets 3

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MGI:1917117

Summaries

All 88

Developmental Gene Expression 6

Gene Ontology 22

Phenotypes 42
Earliest

J:58659 Fu Y, et al., Cloning of DLM-1, a novel gene that is up-regulated in activated macrophages, using RNA differential display. Gene. 1999 Nov 15;240(1):157-63
Latest

J:352540 Yang X, et al., Excessive nucleic acid R-loops induce mitochondria-dependent epithelial cell necroptosis and drive spontaneous intestinal inflammation. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2307395120

TSS for Zbp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr27980	Chr2:173060754-173060768 (-)	-46 bp
Tssr27979	Chr2:173060672-173060724 (-)	17 bp
Tssr27978	Chr2:173060649-173060669 (-)	56 bp
Tssr27977	Chr2:173060611-173060626 (-)	96 bp
Tssr783	Chr2:173060586-173060595 (-)	124 bp
Tssr27976	Chr2:173059462-173059508 (-)	1,230 bp
Tssr27975	Chr2:173058783-173058806 (-)	1,920 bp
Tssr27974	Chr2:173058754-173058780 (-)	1,948 bp
Tssr27973	Chr2:173058660-173058676 (-)	2,047 bp
Tssr27972	Chr2:173057600-173057635 (-)	3,097 bp
Tssr27971	Chr2:173057557-173057598 (-)	3,137 bp
Tssr27970	Chr2:173055707-173055714 (-)	5,004 bp
Tssr27969	Chr2:173055593-173055608 (-)	5,114 bp
Tssr27968	Chr2:173053587-173053602 (-)	7,120 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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