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Rgs18 Gene Detail
Summary
  • Symbol
    Rgs18
  • Name
    regulator of G-protein signaling 18
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927498
    NCBI Gene: 64214
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:144628430-144651165 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 62.99 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    759 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927498
 protein coding gene Chr1:144628421-144651173 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016569
 protein coding gene Chr1:149134685-149158822 (-)
A/J MGP_AJ_G0016552
 protein coding gene Chr1:143168412-143191159 (-)
AKR/J MGP_AKRJ_G0016517
 protein coding gene Chr1:147581185-147603924 (-)
BALB/cJ MGP_BALBcJ_G0016512
 protein coding gene Chr1:143613337-143638114 (-)
C3H/HeJ MGP_C3HHeJ_G0016337
 protein coding gene Chr1:147691448-147714829 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016973
 protein coding gene Chr1:154146418-154180022 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014682
 protein coding gene Chr1:135959586-135984407 (-)
CAST/EiJ MGP_CASTEiJ_G0015916
 protein coding gene Chr1:147108688-147137009 (-)
CBA/J MGP_CBAJ_G0016311
 protein coding gene Chr1:159636552-159663979 (-)
DBA/2J MGP_DBA2J_G0016417
 protein coding gene Chr1:142272555-142295101 (-)
FVB/NJ MGP_FVBNJ_G0016415
 protein coding gene Chr1:140747966-140770585 (-)
LP/J MGP_LPJ_G0016488
 protein coding gene Chr1:150134184-150158015 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016441
 protein coding gene Chr1:166112399-166159739 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017009
 protein coding gene Chr1:147311100-147334803 (-)
PWK/PhJ MGP_PWKPhJ_G0015702
 protein coding gene Chr1:141179458-141207601 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015489
 protein coding gene Chr1:146090737-146114142 (-)
WSB/EiJ MGP_WSBEiJ_G0015979
 protein coding gene Chr1:147357306-147381714 (-)



Homology
more
  • Human Ortholog
    RGS18, regulator of G protein signaling 18
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RGS18, regulator of G protein signaling 18
  • Synonyms
    RGS13
  • Links
    NCBI Gene ID: 64407
    neXtProt AC: NX_Q9NS28
    UniProt: Q9NS28

  • Chr Location
    1q31.2; chr1:192158462-192185815 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show reduced thermal nociception threshold, increased startle reflex, thrombocytopenia, defective megakaryopoiesis, and increased platelet aggregation. Homozygotes for a different null allele show decreased bleeding time, increased platelet aggregation, and thrombosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    751
  • Tissues
    15
  • cDNA Data
    10
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 64214 NCBI Gene Model | MGI Sequence Detail 22736 C57BL/6J ±  kb
transcript NM_022881 RefSeq | MGI Sequence Detail 2014 ZRU/MplStud  
polypeptide Q99PG4 UniProt | EBI | MGI Sequence Detail 235 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:65933 Park IK, et al., Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells. J Biol Chem. 2001 Jan 12;276(2):915-23
  • Latest
    J:304369 DeHelian D, et al., RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival. Blood. 2020 Oct 8;136(15):1773-1782
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory