Tas1r1 MGI Mouse Gene Detail - MGI:1927505 - taste receptor, type 1, member 1

Symbol

Tas1r1
Name

taste receptor, type 1, member 1
Synonyms

Gpr70, T1r1, T1R1, TR1

Feature Type

protein coding gene
IDs

MGI:1927505
NCBI Gene: 110326
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr4:152112371-152122947 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 82.83 cM
Mapping Data

7 experiments

SNPs within 2kb

409 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927505	protein coding gene	Chr4:152112371-152123025 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029169	protein coding gene	Chr4:156126314-156137524 (-)
A/J	MGP_AJ_G0029134	protein coding gene	Chr4:149561989-149573646 (-)
AKR/J	MGP_AKRJ_G0029082	protein coding gene	Chr4:153642951-153653512 (-)
BALB/cJ	MGP_BALBcJ_G0029150	protein coding gene	Chr4:150048789-150059779 (-)
C3H/HeJ	MGP_C3HHeJ_G0028871	protein coding gene	Chr4:154204984-154217431 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029599	protein coding gene	Chr4:161709917-161720587 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026845	protein coding gene	Chr4:141929456-141940578 (-)
CAST/EiJ	MGP_CASTEiJ_G0028284	protein coding gene	Chr4:151546375-151558332 (-)
CBA/J	MGP_CBAJ_G0028833	protein coding gene	Chr4:166525397-166537598 (-)
DBA/2J	MGP_DBA2J_G0028982	protein coding gene	Chr4:149623492-149635448 (-)
FVB/NJ	MGP_FVBNJ_G0028946	protein coding gene	Chr4:148780869-148793197 (-)
LP/J	MGP_LPJ_G0029072	protein coding gene	Chr4:156039355-156051332 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028973	protein coding gene	Chr4:169569425-169581216 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029631	protein coding gene	Chr4:154176880-154187542 (-)
PWK/PhJ	MGP_PWKPhJ_G0028004	protein coding gene	Chr4:145694448-145705375 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027838	protein coding gene	Chr4:148455248-148469579 (-)
WSB/EiJ	MGP_WSBEiJ_G0028364	protein coding gene	Chr4:154339929-154350342 (-)

Human Ortholog

TAS1R1, taste 1 receptor member 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TAS1R1, taste 1 receptor member 1
Synonyms

GM148, GPR70, T1R1, TR1
Links

HGNC:14448

NCBI Gene ID: 80835

neXtProt AC: NX_Q7RTX1

UniProt: Q7RTX1
Chr Location

1p36.31; chr1:6555307-6579755 (+) GRCh38

MGI Vertebrate Homology

Tas1r1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TAS1R1
Gene Tree

Tas1r1

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

1
Gene trapped

1
Targeted

9
Genomic Mutations

3 involving Tas1r1
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice show diminished behavioral and nervous responses to umami tastants. Response to sweet tastants is unimpaired.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

1
cDNA Data

10
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tas1r1

ZFIN tas1r1

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All Sequences

36
RefSeq

4
UniProt

2
CCDS

CCDS18985.1

Ensembl

ENSMUSG00000028950 (Evidence)
NCBI Gene

110326

			Length	Strain/Species	Flank
genomic	110326	NCBI Gene Model \| MGI Sequence Detail	10577	C57BL/6J	± kb
transcript	NM_031867	RefSeq \| MGI Sequence Detail	2814	ZRU/MplStud
polypeptide	Q99PG6	UniProt \| EBI \| MGI Sequence Detail	842	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016060 taste receptor type 1 member 1

(term hierarchy)
InterPro Domains

IPR000337 GPCR, family 3

IPR017979 GPCR, family 3, conserved site

IPR017978 GPCR family 3, C-terminal

IPR000068 GPCR, family 3, extracellular calcium-sensing receptor-related

IPR011500 GPCR, family 3, nine cysteines domain

IPR038550 GPCR, family 3, nine cysteines domain superfamily

IPR028082 Periplasmic binding protein-like I

IPR001828 Receptor, ligand binding region
GlyGen

Q99PG6 7 sites

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All nucleic 14

Genomic 2

cDNA 10

Primer pair 2

Microarray probesets 3

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MGI:1340021

Summaries

All 61

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 20
Earliest

J:53048 Hoon MA, et al., Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell. 1999 Feb 19;96(4):541-51
Latest

J:335201 Ohmoto M, et al., A Transcription Factor Etv1/Er81 Is Involved in the Differentiation of Sweet, Umami, and Sodium Taste Cells. eNeuro. 2023 Apr;10(4):ENEURO.0236-22.2023

TSS for Tas1r1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr44804	Chr4:152122891-152122902 (-)	50 bp
Tssr44803	Chr4:152118210-152118217 (-)	4,733 bp
Tssr44802	Chr4:152115834-152115850 (-)	7,105 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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