Ykt6 MGI Mouse Gene Detail - MGI:1927550 - YKT6 v-SNARE homolog (S. cerevisiae)

Symbol

Ykt6
Name

YKT6 v-SNARE homolog (S. cerevisiae)
Synonyms

0610042I15Rik, 1810013M05Rik

Feature Type

protein coding gene
IDs

MGI:1927550
NCBI Gene: 56418
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:5905779-5917780 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 3.89 cM
Mapping Data

2 experiments

SNPs within 2kb

299 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927550	protein coding gene	Chr11:5905693-5917780 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018013	protein coding gene	Chr11:3050207-3062296 (+)
A/J	MGP_AJ_G0017986	protein coding gene	Chr11:2928628-2940734 (+)
AKR/J	MGP_AKRJ_G0017950	protein coding gene	Chr11:3076602-3088706 (+)
BALB/cJ	MGP_BALBcJ_G0017954	protein coding gene	Chr11:2916877-2928910 (+)
C3H/HeJ	MGP_C3HHeJ_G0017767	protein coding gene	Chr11:2951934-2964029 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018406	protein coding gene	Chr11:3128620-3140707 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016064	protein coding gene	Chr11:2825828-2837599 (+)
CAST/EiJ	MGP_CASTEiJ_G0017329	protein coding gene	Chr11:2924837-2936921 (+)
CBA/J	MGP_CBAJ_G0017742	protein coding gene	Chr11:3513400-3525485 (+)
DBA/2J	MGP_DBA2J_G0017852	protein coding gene	Chr11:2832759-2844846 (+)
FVB/NJ	MGP_FVBNJ_G0017844	protein coding gene	Chr11:2859642-2871694 (+)
LP/J	MGP_LPJ_G0017923	protein coding gene	Chr11:3128095-3140128 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017870	protein coding gene	Chr11:3109990-3122063 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018446	protein coding gene	Chr11:3093228-3105327 (+)
PWK/PhJ	MGP_PWKPhJ_G0017109	protein coding gene	Chr11:2857069-2869276 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016906	protein coding gene	Chr11:3049350-3061537 (+)
WSB/EiJ	MGP_WSBEiJ_G0017383	protein coding gene	Chr11:2924652-2936749 (+)

Human Ortholog

YKT6, YKT6 v-SNARE homolog

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

YKT6, YKT6 v-SNARE homolog
Links

HGNC:16959

NCBI Gene ID: 10652

neXtProt AC: NX_O15498

UniProt: O15498
Chr Location

7p13; chr7:44200959-44214294 (+) GRCh38

MGI Vertebrate Homology

Ykt6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: YKT6
Gene Tree

Ykt6

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
1 images
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Gene trapped

2
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available

Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, blastocysts fail to hatch from the zona pellucida and die after 3 days in culture.

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All GO Annotations

40
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

124
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ykt6

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All Sequences

40
RefSeq

2
UniProt

1
CCDS

CCDS24410.1

Ensembl

ENSMUSG00000002741 (Evidence)
NCBI Gene

56418

			Length	Strain/Species	Flank
genomic	56418	NCBI Gene Model \| MGI Sequence Detail	12002	C57BL/6J	± kb
transcript	NM_019661	RefSeq \| MGI Sequence Detail	2455	C57BL/6
polypeptide	Q9CQW1	UniProt \| EBI \| MGI Sequence Detail	198	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017539 synaptobrevin homolog YKT6

(term hierarchy)
EC

2.3.1.-
InterPro Domains

IPR010908 Longin domain

IPR011012 Longin-like domain superfamily

IPR042855 v-SNARE, coiled-coil homology domain

IPR045848 YKT6, SNARE motif

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All nucleic 125

cDNA 124

Other 1

Microarray probesets 5

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MGI:1915642, MGI:1923744, MGI:2144493

Summaries

All 41

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 8
Earliest

J:41722 McNew JA, et al., Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport. J Biol Chem. 1997 Jul 11;272(28):17776-83
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ykt6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100217	Chr11:5905754-5905821 (+)	9 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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