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Dhx38 Gene Detail
Summary
  • Symbol
    Dhx38
  • Name
    DEAH-box helicase 38
  • Synonyms
    5730550P09Rik, Ddx38, Prp16
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927617
    NCBI Gene: 64340
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:110274643-110292493 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.09 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    532 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927617
 protein coding gene Chr8:110274631-110292493 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034106
 protein coding gene Chr8:112148208-112165776 (-)
A/J MGP_AJ_G0034086
 protein coding gene Chr8:107589072-107606636 (-)
AKR/J MGP_AKRJ_G0034012
 protein coding gene Chr8:110757251-110774820 (-)
BALB/cJ MGP_BALBcJ_G0034079
 protein coding gene Chr8:107813343-107830912 (-)
C3H/HeJ MGP_C3HHeJ_G0033791
 protein coding gene Chr8:111467389-111484966 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034599
 protein coding gene Chr8:116114050-116131614 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031541
 protein coding gene Chr8:100641359-100658636 (-)
CAST/EiJ MGP_CASTEiJ_G0033118
 protein coding gene Chr8:111064026-111081686 (-)
CBA/J MGP_CBAJ_G0033764
 protein coding gene Chr8:120009015-120026585 (-)
DBA/2J MGP_DBA2J_G0033919
 protein coding gene Chr8:106930419-106948179 (-)
FVB/NJ MGP_FVBNJ_G0033864
 protein coding gene Chr8:105880205-105897783 (-)
LP/J MGP_LPJ_G0034010
 protein coding gene Chr8:112323644-112342796 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033909
 protein coding gene Chr8:123029801-123047365 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034618
 protein coding gene Chr8:110720003-110737572 (-)
PWK/PhJ MGP_PWKPhJ_G0032820
 protein coding gene Chr8:106493658-106511380 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032659
 protein coding gene Chr8:109402766-109420514 (-)
WSB/EiJ MGP_WSBEiJ_G0033233
 protein coding gene Chr8:111402424-111421075 (-)



Homology
more
  • Human Ortholog
    DHX38, DEAH-box helicase 38
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DHX38, DEAH-box helicase 38
  • Synonyms
    DDX38, PRP16, PRPF16, RP84
  • Links
    NCBI Gene ID: 9785
    neXtProt AC: NX_Q92620
    UniProt: Q92620

  • Chr Location
    16q22.2; chr16:72093613-72112912 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DHX38 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    97
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037993 Ensembl Gene Model | MGI Sequence Detail 17851 C57BL/6J ±  kb
    transcript ENSMUST00000042601 Ensembl | MGI Sequence Detail 4463 Not Applicable  
    polypeptide ENSMUSP00000047865 Ensembl | MGI Sequence Detail 1228 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
      3.6.4.13
    • InterPro Domains
      IPR011709 DEAD-box helicase, OB fold
      IPR011545 DEAD/DEAH box helicase domain
      IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
      IPR007502 Helicase-associated domain
      IPR048333 Helicase associated domain (HA2), winged-helix domain
      IPR001650 Helicase, C-terminal domain-like
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 97

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917918, MGI:2142512, MGI:2142797
    References
    more
    • Summaries
      All 32
      Gene Ontology 2
      Phenotypes 9
    • Earliest
      J:62630 Chu CC, et al., Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol. 1998 Jun;35(8):487-502
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory