Sp5 MGI Mouse Gene Detail - MGI:1927715 - trans-acting transcription factor 5

Symbol

Sp5
Name

trans-acting transcription factor 5

Feature Type

protein coding gene
IDs

MGI:1927715
NCBI Gene: 64406
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:70305267-70308070 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 41.49 cM
Mapping Data

2 experiments

SNPs within 2kb

134 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927715	protein coding gene	Chr2:70305267-70308073 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025811	protein coding gene	Chr2:70520120-70522923 (+)
A/J	MGP_AJ_G0025788	protein coding gene	Chr2:67780275-67783042 (+)
AKR/J	MGP_AKRJ_G0025757	protein coding gene	Chr2:69623439-69626206 (+)
BALB/cJ	MGP_BALBcJ_G0025783	protein coding gene	Chr2:67966686-67969453 (+)
C3H/HeJ	MGP_C3HHeJ_G0025543	protein coding gene	Chr2:69846384-69849151 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026230	protein coding gene	Chr2:72641812-72644612 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023633	protein coding gene	Chr2:65010366-65013114 (+)
CAST/EiJ	MGP_CASTEiJ_G0025007	protein coding gene	Chr2:69996200-70000496 (+)
CBA/J	MGP_CBAJ_G0025523	protein coding gene	Chr2:75337329-75340096 (+)
DBA/2J	MGP_DBA2J_G0025654	protein coding gene	Chr2:67413658-67416425 (+)
FVB/NJ	MGP_FVBNJ_G0025617	protein coding gene	Chr2:66785828-66788595 (+)
LP/J	MGP_LPJ_G0025743	protein coding gene	Chr2:70363500-70366265 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025646	protein coding gene	Chr2:77361713-77364480 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026287	protein coding gene	Chr2:69717732-69720499 (+)
PWK/PhJ	MGP_PWKPhJ_G0024748	protein coding gene	Chr2:67264060-67266927 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024555	protein coding gene	Chr2:69932515-69935275 (+)
WSB/EiJ	MGP_WSBEiJ_G0025075	protein coding gene	Chr2:70151638-70154417 (+)

Human Ortholog

SP5, Sp5 transcription factor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SP5, Sp5 transcription factor
Links

HGNC:14529

NCBI Gene ID: 389058

neXtProt AC: NX_Q6BEB4

UniProt: Q6BEB4
Chr Location

2q31.1; chr2:170715337-170718078 (+) GRCh38

MGI Vertebrate Homology

Sp5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SP5
Gene Tree

Sp5

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
4 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

5
Genomic Mutations

1 involving Sp5
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted mutation in this gene are fertile and show no overt phenotype.

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All GO Annotations

14
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1067
Tissues

184
cDNA Data

12
Literature Summary

45

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SP5

Xenbase sp5

ZFIN sp5a

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS16106.1

Ensembl

ENSMUSG00000075304 (Evidence)
NCBI Gene

64406

			Length	Strain/Species	Flank
genomic	64406	NCBI Gene Model \| MGI Sequence Detail	2804	C57BL/6J	± kb
transcript	NM_022435	RefSeq \| MGI Sequence Detail	2097	ZRU/MplStud
polypeptide	Q9JHX2	UniProt \| EBI \| MGI Sequence Detail	398	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015443 transcription factor Sp5

(term hierarchy)
InterPro Domains

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 23

cDNA 14

Primer pair 5

Other 4

Microarray probesets 3

Summaries

All 81

Developmental Gene Expression 45

Gene Ontology 8

Phenotypes 15
Earliest

J:65743 Harrison SM, et al., Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with brachyury. Dev Biol. 2000 Nov 15;227(2):358-72
Latest

J:352711 Zhao R, et al., Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination. Elife. 2024 Jun 14;13

TSS for Sp5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18195	Chr2:70305455-70305471 (+)	196 bp
Tssr18196	Chr2:70306299-70306313 (+)	1,039 bp
Tssr18197	Chr2:70306327-70306348 (+)	1,071 bp
Tssr18198	Chr2:70306395-70306436 (+)	1,149 bp
Tssr517	Chr2:70306506-70306544 (+)	1,258 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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