Fcamr MGI Mouse Gene Detail - MGI:1927803 - Fc receptor, IgA, IgM, high affinity

Symbol

Fcamr
Name

Fc receptor, IgA, IgM, high affinity

Feature Type

protein coding gene
IDs

MGI:1927803
NCBI Gene: 64435
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:130728639-130742477 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 56.89 cM, cytoband F
Mapping Data

2 experiments

SNPs within 2kb

652 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927803	protein coding gene	Chr1:130712444-130753641 (+)
129S1/SvImJ	ENSMUSG00200007545	protein coding gene	Chr1:128299510-128313359 (+)
A/J	ENSMUSG00195041327	protein coding gene	Chr1:127390870-127404716 (+)
AKR/J	ENSMUSG00220046094	protein coding gene	Chr1:127236973-127250782 (+)
BALB/cJ	ENSMUSG00180037222	protein coding gene	Chr1:127954069-127967908 (+)
C3H/HeJ	ENSMUSG00175040619	protein coding gene	Chr1:127635585-127649429 (+)
C57BL/6NJ	ENSMUSG00215045132	protein coding gene	Chr1:127651218-127665060 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014559	protein coding gene	Chr1:122378275-122392170 (+)
CAST/EiJ	ENSTCUG00005030546	protein coding gene	Chr1:126573213-126587016 (+)
CBA/J	ENSMUSG00210026802	protein coding gene	Chr1:127553921-127567726 (+)
DBA/2J	ENSMUSG00185001800	protein coding gene	Chr1:131898324-131912173 (+)
FVB/NJ	ENSMUSG00205027952	protein coding gene	Chr1:126856103-126869950 (+)
JF1/MsJ	ENSUMUG00000001107	protein coding gene	Chr1:131073326-131087239 (+)
LP/J	ENSMUSG00230000863	protein coding gene	Chr1:131477706-131491552 (+)
NOD/ShiLtJ	ENSMUSG00190035191	protein coding gene	Chr1:127545521-127559372 (+)
NZO/HlLtJ	ENSMUSG00225016768	protein coding gene	Chr1:135214490-135228334 (+)
PWK/PhJ	ENSLUMG00010026771	protein coding gene	Chr1:126679318-126693111 (+)
SPRET/EiJ	ENSMSPG00010038376	protein coding gene	Chr1:129477448-129491295 (+)
WSB/EiJ	ENSIUOG00005047483	protein coding gene	Chr1:127298007-127311819 (+)

Human Ortholog

FCAMR, Fc alpha and mu receptor

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FCAMR, Fc alpha and mu receptor
Synonyms

CD351, Fcalpha/muR, FCA/MR, FKSG87
Links

HGNC:24692

NCBI Gene ID: 83953

UniProt: Q8WWV6
Chr Location

1q32.1; chr1:206957965-206970638 (-) GRCh38

MGI Vertebrate Homology

Fcamr stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: FCAMR
Gene Tree

Fcamr

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

1
Targeted

8
Genomic Mutations

3 involving Fcamr
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice have enhanced germinal center formation, affinity maturation and memory induction of IgG3 producing B cells after immunization with T cell-independent antigens.

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All GO Annotations

9
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

607
Tissues

7
cDNA Data

5
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

46
RefSeq

16
UniProt

1
CCDS

CCDS15259.1, CCDS48353.1

Ensembl

ENSMUSG00000026415 (Evidence)
NCBI Gene

64435

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026415	Ensembl Gene Model \| MGI Sequence Detail	13839	C57BL/6J	± kb
transcript	ENSMUST00000112477	Ensembl \| MGI Sequence Detail	1879	Not Applicable
polypeptide	ENSMUSP00000108096	Ensembl \| MGI Sequence Detail	591	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007430 high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor

(term hierarchy)
InterPro Domains

IPR050671 CD300 family immune receptors

IPR003599 Immunoglobulin domain subtype

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR013106 Immunoglobulin V-set domain
GlyGen

Q2TB54 4 sites

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All nucleic 7

Genomic 2

cDNA 5

Antibodies 1

Microarray probesets 2

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:283544 Noval Rivas M, et al., Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation. Immunity. 2019 Sep 17;51(3):508-521.e6

TSS for Fcamr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8570	Chr1:130728372-130728377 (+)	-264 bp
Tssr8571	Chr1:130730819-130730828 (+)	2,185 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24