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Pex14 Gene Detail
Summary
  • Symbol
    Pex14
  • Name
    peroxisomal biogenesis factor 14
  • Synonyms
    Pex14p
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927868
    NCBI Gene: 56273
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:149044992-149184300 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 78.87 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1257 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927868
 protein coding gene Chr4:149044992-149184333 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029132
 protein coding gene Chr4:152742016-152904193 (-)
A/J MGP_AJ_G0029097
 protein coding gene Chr4:146401460-146542150 (-)
AKR/J MGP_AKRJ_G0029045
 protein coding gene Chr4:150402210-150551955 (-)
BALB/cJ MGP_BALBcJ_G0029113
 protein coding gene Chr4:146910173-147050721 (-)
C3H/HeJ MGP_C3HHeJ_G0028834
 protein coding gene Chr4:150959524-151111904 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029562
 protein coding gene Chr4:158272321-158423982 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026808
 protein coding gene Chr4:138824102-138968567 (-)
CAST/EiJ MGP_CASTEiJ_G0028247
 protein coding gene Chr4:148178552-148327394 (-)
CBA/J MGP_CBAJ_G0028796
 protein coding gene Chr4:162905860-163071851 (-)
DBA/2J MGP_DBA2J_G0028945
 protein coding gene Chr4:146510740-146655718 (-)
FVB/NJ MGP_FVBNJ_G0028909
 protein coding gene Chr4:145616999-145756885 (-)
LP/J MGP_LPJ_G0029035
 protein coding gene Chr4:152699399-152851435 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028936
 protein coding gene Chr4:166169277-166319634 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029594
 protein coding gene Chr4:150896623-151044701 (-)
PWK/PhJ MGP_PWKPhJ_G0027967
 protein coding gene Chr4:142506249-142651370 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027801
 protein coding gene Chr4:145138524-145280301 (-)
WSB/EiJ MGP_WSBEiJ_G0028327
 protein coding gene Chr4:151056906-151204035 (-)



Homology
more
  • Human Ortholog
    PEX14, peroxisomal biogenesis factor 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PEX14, peroxisomal biogenesis factor 14
  • Synonyms
    dJ734G22.2, NAPP2, PBD13A, Pex14p
  • Links
    NCBI Gene ID: 5195
    neXtProt AC: NX_O75381
    UniProt: O75381

  • Chr Location
    1p36.22; chr1:10472288-10630758 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PEX14 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this locus results in embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    93
  • cDNA Data
    91
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56273 NCBI Gene Model | MGI Sequence Detail 139309 C57BL/6J ±  kb
transcript NM_019781 RefSeq | MGI Sequence Detail 1973 C57BL/6  
polypeptide Q9R0A0 UniProt | EBI | MGI Sequence Detail 376 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012560 peroxisomal membrane protein PEX14
    (term hierarchy)
  • InterPro Domains
    IPR025655 Peroxisomal membrane protein 14
    IPR006785 Peroxisome membrane anchor protein Pex14p, N-terminal
    IPR036388 Winged helix-like DNA-binding domain superfamily
  • GlyGen
    Q9R0A0 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 95
    cDNA 94
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2140717
References
more
  • Summaries
    All 51
    Developmental Gene Expression 6
    Gene Ontology 10
    Phenotypes 15
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:348785 Zhang D, et al., Maternal Ezh1/2 deficiency impairs the function of mitochondria in mouse oocytes and early embryos. J Cell Physiol. 2024 Mar 26;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory