Selenof MGI Mouse Gene Detail - MGI:1927947

Symbol

Selenof
Name

selenoprotein F
Synonyms

9430015P09Rik, Sep15

Feature Type

protein coding gene
IDs

MGI:1927947
NCBI Gene: 93684
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr3:144276188-144303438 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 68.94 cM, cytoband H3
Mapping Data

3 experiments

SNPs within 2kb

978 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927947	protein coding gene	Chr3:144276065-144303441 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027951	protein coding gene	Chr3:147881871-147909320 (+)
A/J	MGP_AJ_G0027908	protein coding gene	Chr3:142636166-142664015 (+)
AKR/J	MGP_AKRJ_G0027874	protein coding gene	Chr3:146448539-146479974 (+)
BALB/cJ	MGP_BALBcJ_G0027920	protein coding gene	Chr3:142434419-142461601 (+)
C3H/HeJ	MGP_C3HHeJ_G0027650	protein coding gene	Chr3:146760667-146788449 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028364	protein coding gene	Chr3:152976752-153004982 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025702	protein coding gene	Chr3:137781204-137805262 (+)
CAST/EiJ	MGP_CASTEiJ_G0027106	protein coding gene	Chr3:146736626-146763602 (+)
CBA/J	MGP_CBAJ_G0027627	protein coding gene	Chr3:158214424-158241935 (+)
DBA/2J	MGP_DBA2J_G0027766	protein coding gene	Chr3:141795271-141825469 (+)
FVB/NJ	MGP_FVBNJ_G0027733	protein coding gene	Chr3:139193000-139220352 (+)
LP/J	MGP_LPJ_G0027876	protein coding gene	Chr3:149298746-149325967 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027765	protein coding gene	Chr3:166567264-166597771 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028422	protein coding gene	Chr3:146059005-146087358 (+)
PWK/PhJ	MGP_PWKPhJ_G0026830	protein coding gene	Chr3:141609382-141636846 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026657	protein coding gene	Chr3:144217751-144243463 (+)
WSB/EiJ	MGP_WSBEiJ_G0027185	protein coding gene	Chr3:146946011-146974088 (+)

Human Ortholog

SELENOF, selenoprotein F

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SELENOF, selenoprotein F
Synonyms

SEP15
Links

HGNC:17705

NCBI Gene ID: 9403

neXtProt AC: NX_O60613

UniProt: O60613
Chr Location

1p22.3; chr1:86862445-86914577 (-) GRCh38

MGI Vertebrate Homology

Selenof stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SELENOF
Gene Tree

Selenof

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References

1 with disease annotations

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
3 images
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Endonuclease-mediated

2
Gene trapped

21
Radiation induced

1
Targeted

2
Genomic Mutations

1 involving Selenof
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit mild oxidative stress in the liver and develop cataracts by 1.5 months of age.

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All GO Annotations

10
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase selenof

ZFIN selenof

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All Sequences

57
RefSeq

2
UniProt

4
CCDS

CCDS17884.1

Ensembl

ENSMUSG00000037072 (Evidence)
NCBI Gene

93684

			Length	Strain/Species	Flank
genomic	93684	NCBI Gene Model \| MGI Sequence Detail	27251	C57BL/6J	± kb
transcript	NM_053102	RefSeq \| MGI Sequence Detail	1515	C57BL/6
polypeptide	Q9ERR7	UniProt \| EBI \| MGI Sequence Detail	162	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014642 selenoprotein F

(term hierarchy)
InterPro Domains

IPR039992 Selenoprotein F/M

IPR014912 Selenoprotein F/M domain

IPR038219 Selenoprotein F/M, thioredoxin-like domain superfamily

IPR036249 Thioredoxin-like superfamily

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All nucleic 10

cDNA 10

Microarray probesets 4

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MGI:1924524

Summaries

All 47

Developmental Gene Expression 3

Diseases 1

Gene Ontology 6

Phenotypes 16
Earliest

J:46968 Gladyshev VN, et al., A new human selenium-containing protein. Purification, characterization, and cDNA sequence. J Biol Chem. 1998 Apr 10;273(15):8910-5
Latest

J:331488 Lee TJ, et al., The role of selenoproteins in neutrophils during inflammation. Arch Biochem Biophys. 2022 Nov 3;732:109452

TSS for Selenof:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr32262	Chr3:144275743-144275750 (+)	-441 bp
Tssr32263	Chr3:144276040-144276045 (+)	-145 bp
Tssr32264	Chr3:144276065-144276070 (+)	-120 bp
Tssr32265	Chr3:144276133-144276144 (+)	-49 bp
Tssr32266	Chr3:144276157-144276168 (+)	-25 bp
Tssr32267	Chr3:144276170-144276251 (+)	23 bp
Tssr32268	Chr3:144276317-144276332 (+)	137 bp
Tssr32269	Chr3:144276448-144276482 (+)	277 bp
Tssr32270	Chr3:144283355-144283375 (+)	7,177 bp
Tssr32271	Chr3:144302806-144302859 (+)	26,645 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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