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Mlxipl Gene Detail
Summary
  • Symbol
    Mlxipl
  • Name
    MLX interacting protein-like
  • Synonyms
    bHLHd14, ChREBP, Wbscr14, WS-bHLH
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927999
    NCBI Gene: 58805
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:135118744-135167236 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 75.00 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1301 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927999
 protein coding gene Chr5:135118744-135168622 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030174
 protein coding gene Chr5:139588381-139639618 (+)
A/J MGP_AJ_G0030142
 protein coding gene Chr5:133614007-133664546 (+)
AKR/J MGP_AKRJ_G0030075
 protein coding gene Chr5:137957239-138010634 (+)
BALB/cJ MGP_BALBcJ_G0030152
 protein coding gene Chr5:134972053-135023802 (+)
C3H/HeJ MGP_C3HHeJ_G0029868
 protein coding gene Chr5:138520067-138573728 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030605
 protein coding gene Chr5:144813508-144866514 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027828
 protein coding gene Chr5:127912256-127961456 (+)
CAST/EiJ MGP_CASTEiJ_G0029277
 protein coding gene Chr5:137939479-137989393 (+)
CBA/J MGP_CBAJ_G0029838
 protein coding gene Chr5:150480357-150537821 (+)
DBA/2J MGP_DBA2J_G0029989
 protein coding gene Chr5:133517572-133566943 (+)
FVB/NJ MGP_FVBNJ_G0029944
 protein coding gene Chr5:132651719-132700715 (+)
LP/J MGP_LPJ_G0030077
 protein coding gene Chr5:140036408-140086720 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029976
 protein coding gene Chr5:153495973-153548934 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030645
 protein coding gene Chr5:137704529-137754010 (+)
PWK/PhJ MGP_PWKPhJ_G0028992
 protein coding gene Chr5:132559266-132608720 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028827
 protein coding gene Chr5:135267849-135318145 (+)
WSB/EiJ MGP_WSBEiJ_G0029351
 protein coding gene Chr5:138456468-138508335 (+)



Homology
more
  • Human Ortholog
    MLXIPL, MLX interacting protein like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MLXIPL, MLX interacting protein like
  • Synonyms
    bHLHd14, CHREBP, MIO, MLX, MONDOB, WBSCR14, WS-bHLH
  • Links
    NCBI Gene ID: 51085
    neXtProt AC: NX_Q9NP71
    UniProt: Q9NP71

  • Chr Location
    7q11.23; chr7:73593194-73647907 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mlxipl mouse models; 2 with human MLXIPL associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 1 allele in 2 genetic backgrounds
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced glycolysis and lipogenesis and severe simple carbohydrate intolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    935
  • Tissues
    169
  • cDNA Data
    27
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005373 Ensembl Gene Model | MGI Sequence Detail 48493 C57BL/6J ±  kb
    transcript ENSMUST00000005507 Ensembl | MGI Sequence Detail 3622 Not Applicable  
    polypeptide ENSMUSP00000005507 Ensembl | MGI Sequence Detail 864 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000010460 carbohydrate-responsive element-binding protein
      (term hierarchy)
    • PDB
      4GNT
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR052207 Max-like/E-box-binding transcription factors
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    • GlyGen
      Q99MZ3 3 sites, 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 5
      cDNA 28
      Primer pair 3
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 143
      Developmental Gene Expression 19
      Diseases 3
      Gene Ontology 16
      Phenotypes 55
    • Earliest
      J:61965 de Luis O, et al., WBSCR14, a putative transcription factor gene deleted in Williams-Beuren syndrome: complete characterisation of the human gene and the mouse ortholog. Eur J Hum Genet. 2000 Mar;8(3):215-22
    • Latest
      J:358008 Zhang D, et al., Suppression of hepatic ChREBP-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASH. Mol Metab. 2024 May 11;85:101957
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory