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Tspan4 Gene Detail
Summary
  • Symbol
    Tspan4
  • Name
    tetraspanin 4
  • Synonyms
    D130042I01Rik, NAG-2, novel antigen 2, Tm4sf7, Tspan-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928097
    NCBI Gene: 64540
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:141055194-141073340 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 86.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    465 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928097
 protein coding gene Chr7:141055153-141073340 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033236
 protein coding gene Chr7:146668507-146686096 (+)
A/J MGP_AJ_G0033217
 protein coding gene Chr7:142472526-142492045 (+)
AKR/J MGP_AKRJ_G0033150
 protein coding gene Chr7:146424533-146442209 (+)
BALB/cJ MGP_BALBcJ_G0033218
 protein coding gene Chr7:142217635-142235073 (+)
C3H/HeJ MGP_C3HHeJ_G0032933
 protein coding gene Chr7:146159857-146180128 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033730
 protein coding gene Chr7:152019640-152037949 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030703
 protein coding gene Chr7:143680605-143699969 (+)
CAST/EiJ MGP_CASTEiJ_G0032263
 protein coding gene Chr7:138473695-138524088 (+)
CBA/J MGP_CBAJ_G0032905
 protein coding gene Chr7:157179309-157198944 (+)
DBA/2J MGP_DBA2J_G0033057
 protein coding gene Chr7:140417969-140436279 (+)
FVB/NJ MGP_FVBNJ_G0033010
 protein coding gene Chr7:140332963-140350905 (+)
LP/J MGP_LPJ_G0033152
 protein coding gene Chr7:148161003-148179936 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033043
 protein coding gene Chr7:157813851-157831369 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033749
 protein coding gene Chr7:145383286-145400737 (+)
PWK/PhJ MGP_PWKPhJ_G0031967
 protein coding gene Chr7:133702883-133748942 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031813
 protein coding gene Chr7:132213564-132233517 (+)
WSB/EiJ MGP_WSBEiJ_G0032373
 protein coding gene Chr7:146331853-146349421 (+)



Homology
more
  • Human Ortholog
    TSPAN4, tetraspanin 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSPAN4, tetraspanin 4
  • Synonyms
    NAG-2, NAG2, TETRASPAN, TM4SF7, TSPAN-4
  • Links
    NCBI Gene ID: 7106
    neXtProt AC: NX_O14817
    UniProt: O14817

  • Chr Location
    11p15.5; chr11:842812-867116 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
Female mice homozygous for a null allele exhibit normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    889
  • Tissues
    18
  • cDNA Data
    11
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64540 NCBI Gene Model | MGI Sequence Detail 18147 C57BL/6J ±  kb
    transcript NM_001403355 RefSeq | MGI Sequence Detail 1887 C57BL/6  
    polypeptide Q9DCK3 UniProt | EBI | MGI Sequence Detail 238 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2141916, MGI:2142025, MGI:2441940
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:44052 Tachibana I, et al., NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. J Biol Chem. 1997 Nov 14;272(46):29181-9
    • Latest
      J:348425 Pham AH, et al., Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice. Cells. 2024;13(10):802
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory