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Ireb2 Gene Detail
Summary
  • Symbol
    Ireb2
  • Name
    iron responsive element binding protein 2
  • Synonyms
    D9Ertd85e, Irp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928268
    NCBI Gene: 64602
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:54771073-54819814 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 29.81 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    889 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928268
 protein coding gene Chr9:54769942-54819814 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034831
 protein coding gene Chr9:53931237-53983332 (+)
A/J MGP_AJ_G0034812
 protein coding gene Chr9:52204955-52253714 (+)
AKR/J MGP_AKRJ_G0034741
 protein coding gene Chr9:53390689-53444545 (+)
BALB/cJ MGP_BALBcJ_G0034804
 protein coding gene Chr9:51986723-52035937 (+)
C3H/HeJ MGP_C3HHeJ_G0034514
 protein coding gene Chr9:53859087-53910426 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035323
 protein coding gene Chr9:55435213-55483977 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032235
 protein coding gene Chr9:51627927-51675400 (+)
CAST/EiJ MGP_CASTEiJ_G0033836
 protein coding gene Chr9:53880300-53929778 (+)
CBA/J MGP_CBAJ_G0034485
 protein coding gene Chr9:57369546-57425185 (+)
DBA/2J MGP_DBA2J_G0034644
 protein coding gene Chr9:52098509-52146821 (+)
FVB/NJ MGP_FVBNJ_G0034586
 protein coding gene Chr9:51298720-51347938 (+)
LP/J MGP_LPJ_G0034727
 protein coding gene Chr9:54242723-54291239 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034629
 protein coding gene Chr9:58894534-58944543 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035345
 protein coding gene Chr9:53416549-53466370 (+)
PWK/PhJ MGP_PWKPhJ_G0033540
 protein coding gene Chr9:52081106-52130619 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033375
 protein coding gene Chr9:53677318-53726900 (+)
WSB/EiJ MGP_WSBEiJ_G0033948
 protein coding gene Chr9:53374594-53423143 (+)



Homology
more
  • Human Ortholog
    IREB2, iron responsive element binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IREB2, iron responsive element binding protein 2
  • Synonyms
    ACO3, IRE-BP 2, IRE-BP2, IRP2, IRP2AD, NDCAMA
  • Links
    NCBI Gene ID: 3658
    neXtProt AC: NX_P48200
    UniProt: P48200

  • Chr Location
    15q25.1; chr15:78437431-78501453 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IREB2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    59 phenotypes from 5 alleles in 6 genetic backgrounds
    11 phenotypes from multigenic genotypes
    6 images
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene results in microcytic anemia, altered body iron homeostasis, and variable behavioral and neurological phenotypes that may include pathological signs of neurodegeneration or brain iron accumulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    822
  • Tissues
    114
  • cDNA Data
    225
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032293 Ensembl Gene Model | MGI Sequence Detail 48742 C57BL/6J ±  kb
    transcript ENSMUST00000034843 Ensembl | MGI Sequence Detail 5770 Not Applicable  
    polypeptide ENSMUSP00000034843 Ensembl | MGI Sequence Detail 963 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000009102 iron-responsive element-binding protein 2
      (term hierarchy)
    • InterPro Domains
      IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain
      IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
      IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel
      IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel domain
      IPR044137 Aconitase A, swivel domain
      IPR018136 Aconitase family, 4Fe-4S cluster binding site
      IPR006249 Aconitase/Iron-responsive element-binding protein 2
      IPR036008 Aconitase, iron-sulfur domain
    • GlyGen
      Q811J3 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 228
      cDNA 225
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1098541
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 10
      Gene Ontology 15
      Phenotypes 53
    • Earliest
      J:66321 Henderson BR, et al., Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements. J Biol Chem. 1993 Dec 25;268(36):27327-34
    • Latest
      J:353157 Liu Y, et al., Stimulation of Hepatic Ferritinophagy Mitigates Irp2 Depletion-Induced Anemia. Antioxidants (Basel). 2023 Feb 24;12(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory