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Dnajc7 Gene Detail
Summary
  • Symbol
    Dnajc7
  • Name
    DnaJ heat shock protein family (Hsp40) member C7
  • Synonyms
    2010003F24Rik, 2010004G07Rik, mDj11, mTpr2, Ttc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928373
    NCBI Gene: 56354
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100473644-100511014 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.47 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    980 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928373
 protein coding gene Chr11:100473644-100511030 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019161
 protein coding gene Chr11:103345530-103386824 (-)
A/J MGP_AJ_G0019129
 protein coding gene Chr11:99034401-99071537 (-)
AKR/J MGP_AKRJ_G0019098
 protein coding gene Chr11:102094985-102136817 (-)
BALB/cJ MGP_BALBcJ_G0019103
 protein coding gene Chr11:99518204-99555878 (-)
C3H/HeJ MGP_C3HHeJ_G0018912
 protein coding gene Chr11:102282071-102319699 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019552
 protein coding gene Chr11:106562303-106600691 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017178
 protein coding gene Chr11:96453191-96491962 (-)
CAST/EiJ MGP_CASTEiJ_G0018466
 protein coding gene Chr11:103257908-103298316 (-)
CBA/J MGP_CBAJ_G0018881
 protein coding gene Chr11:110993680-111038527 (-)
DBA/2J MGP_DBA2J_G0018993
 protein coding gene Chr11:98571004-98608346 (-)
FVB/NJ MGP_FVBNJ_G0018983
 protein coding gene Chr11:98107017-98144496 (-)
LP/J MGP_LPJ_G0019062
 protein coding gene Chr11:103908231-103948468 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019014
 protein coding gene Chr11:110596524-110639228 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019590
 protein coding gene Chr11:102429162-102468095 (-)
PWK/PhJ MGP_PWKPhJ_G0018229
 protein coding gene Chr11:99610994-99649477 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018021
 protein coding gene Chr11:102163989-102208027 (-)
WSB/EiJ MGP_WSBEiJ_G0018515
 protein coding gene Chr11:102412377-102451893 (-)



Homology
more
  • Human Ortholog
    DNAJC7, DnaJ heat shock protein family (Hsp40) member C7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAJC7, DnaJ heat shock protein family (Hsp40) member C7
  • Synonyms
    DJ11, DJC7, TPR2, TTC2
  • Links
    NCBI Gene ID: 7266
    neXtProt AC: NX_Q99615
    UniProt: Q99615

  • Chr Location
    17q21.2; chr17:41976421-42021376 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a knock-out allele exhibit hepatic steatosis and increased serum cholesterol.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    37
  • cDNA Data
    163
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014195 Ensembl Gene Model | MGI Sequence Detail 37371 C57BL/6J ±  kb
    transcript ENSMUST00000239410 Ensembl | MGI Sequence Detail 1900 Not Applicable  
    polypeptide ENSMUSP00000159311 Ensembl | MGI Sequence Detail 579 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 167
      cDNA 167

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1913794, MGI:1914883
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 25
    • Earliest
      J:50799 Liu P, et al., Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics. 1998 Nov;150(3):1155-68
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory