B4galt6 MGI Mouse Gene Detail - MGI:1928380 - UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6

Symbol

B4galt6
Name

UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6

Feature Type

protein coding gene
IDs

MGI:1928380
NCBI Gene: 56386
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr18:20817656-20879461 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 11.48 cM
Mapping Data

1 experiment

SNPs within 2kb

1851 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928380	protein coding gene	Chr18:20817656-20879461 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024183	protein coding gene	Chr18:18263322-18324987 (-)
A/J	MGP_AJ_G0024147	protein coding gene	Chr18:17808053-17870351 (-)
AKR/J	MGP_AKRJ_G0024116	protein coding gene	Chr18:18342044-18409145 (-)
BALB/cJ	MGP_BALBcJ_G0024147	protein coding gene	Chr18:17821197-17884977 (-)
C3H/HeJ	MGP_C3HHeJ_G0023915	protein coding gene	Chr18:18266068-18340591 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024589	protein coding gene	Chr18:19150396-19213433 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022031	protein coding gene	Chr18:16906676-16968582 (-)
CAST/EiJ	MGP_CASTEiJ_G0023388	protein coding gene	Chr18:18057079-18123446 (-)
CBA/J	MGP_CBAJ_G0023883	protein coding gene	Chr18:19623088-19689601 (-)
DBA/2J	MGP_DBA2J_G0024015	protein coding gene	Chr18:17519163-17582428 (-)
FVB/NJ	MGP_FVBNJ_G0023981	protein coding gene	Chr18:17296709-17359454 (-)
LP/J	MGP_LPJ_G0024096	protein coding gene	Chr18:18411702-18482936 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024009	protein coding gene	Chr18:20542224-20606622 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024637	protein coding gene	Chr18:18094584-18159576 (-)
PWK/PhJ	MGP_PWKPhJ_G0023133	protein coding gene	Chr18:17615552-17679184 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022942	protein coding gene	Chr18:18312701-18378365 (-)
WSB/EiJ	MGP_WSBEiJ_G0023453	protein coding gene	Chr18:18019840-18083594 (-)

Human Ortholog

B4GALT6, beta-1,4-galactosyltransferase 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

B4GALT6, beta-1,4-galactosyltransferase 6
Synonyms

B4Gal-T6, beta4Gal-T6
Links

HGNC:929

NCBI Gene ID: 9331

neXtProt AC: NX_Q9UBX8

UniProt: Q9UBX8
Chr Location

18q12.1; chr18:31622246-31724641 (-) GRCh38

MGI Vertebrate Homology

B4galt6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: B4GALT6
Gene Tree

B4galt6

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

60
Endonuclease-mediated

2
Gene trapped

55
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available

Mice homozygous for disruptions in this gene display a normal phenotype with reduced lactosylceramide synthase in MEFs.

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All GO Annotations

21
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

991
Tissues

155
cDNA Data

16
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase b4galt6

ZFIN b4galt6

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All Sequences

52
RefSeq

4
UniProt

5
CCDS

CCDS29086.1

Ensembl

ENSMUSG00000056124 (Evidence)
NCBI Gene

56386

			Length	Strain/Species	Flank
genomic	56386	NCBI Gene Model \| MGI Sequence Detail	61806	C57BL/6J	± kb
transcript	NM_019737	RefSeq \| MGI Sequence Detail	5808	C57BL/6
polypeptide	Q9WVK5	UniProt \| EBI \| MGI Sequence Detail	382	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004610 beta-1,4-galactosyltransferase 6

(term hierarchy)
EC

2.4.1.-, 2.4.1.274
InterPro Domains

IPR003859 Beta-1,4-galactosyltransferase

IPR027791 Galactosyltransferase, C-terminal

IPR027995 Galactosyltransferase, N-terminal

IPR029044 Nucleotide-diphospho-sugar transferases
GlyGen

Q9WVK5 9 sites, 3 N-linked glycans (3 sites)

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All nucleic 17

cDNA 16

Primer pair 1

Microarray probesets 7

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MGI:2147179, MGI:2147314

Summaries

All 46

Developmental Gene Expression 7

Gene Ontology 11

Phenotypes 11
Earliest

J:47946 Nomura T, et al., Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain. J Biol Chem. 1998 May 29;273(22):13570-7
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for B4galt6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr152605	Chr18:20879459-20879479 (-)	-8 bp
Tssr152604	Chr18:20879391-20879451 (-)	40 bp
Tssr152603	Chr18:20879324-20879390 (-)	104 bp
Tssr152602	Chr18:20879284-20879296 (-)	171 bp
Tssr152601	Chr18:20879183-20879192 (-)	273 bp
Tssr152600	Chr18:20878976-20878980 (-)	483 bp
Tssr152599	Chr18:20878936-20878971 (-)	507 bp
Tssr152598	Chr18:20878775-20878796 (-)	675 bp
Tssr152597	Chr18:20878635-20878680 (-)	803 bp
Tssr152596	Chr18:20874085-20874099 (-)	5,369 bp
Tssr152595	Chr18:20871694-20871698 (-)	7,765 bp
Tssr152594	Chr18:20836335-20836343 (-)	43,122 bp
Tssr152593	Chr18:20827793-20827806 (-)	51,661 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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