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Brinp1 Gene Detail
Summary
  • Symbol
    Brinp1
  • Name
    bone morphogenic protein/retinoic acid inducible neural specific 1
  • Synonyms
    Dbc1, Dbccr1, Fam5a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928478
    NCBI Gene: 56710
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:68679751-68872634 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 35.03 cM, cytoband C2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5492 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928478
 protein coding gene Chr4:68679609-68872634 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028380
 protein coding gene Chr4:67947709-68100779 (-)
A/J MGP_AJ_G0028341
 protein coding gene Chr4:65544638-65750839 (-)
AKR/J MGP_AKRJ_G0028290
 protein coding gene Chr4:67254229-67408752 (-)
BALB/cJ MGP_BALBcJ_G0028361
 protein coding gene Chr4:65733570-65945598 (-)
C3H/HeJ MGP_C3HHeJ_G0028076
 protein coding gene Chr4:67841285-68047262 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028801
 protein coding gene Chr4:70301017-70507272 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026104
 protein coding gene Chr4:62485313-62678057 (-)
CAST/EiJ MGP_CASTEiJ_G0027518
 protein coding gene Chr4:65793182-66007227 (-)
CBA/J MGP_CBAJ_G0028045
 protein coding gene Chr4:72648630-72861445 (-)
DBA/2J MGP_DBA2J_G0028194
 protein coding gene Chr4:65337988-65532202 (-)
FVB/NJ MGP_FVBNJ_G0028160
 protein coding gene Chr4:64536570-64731719 (-)
LP/J MGP_LPJ_G0028293
 protein coding gene Chr4:68223285-68433892 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028189
 protein coding gene Chr4:76211290-76419869 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028837
 protein coding gene Chr4:67393721-67597226 (-)
PWK/PhJ MGP_PWKPhJ_G0027244
 protein coding gene Chr4:63856421-64049825 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027070
 protein coding gene Chr4:64941309-65141599 (-)
WSB/EiJ MGP_WSBEiJ_G0027594
 protein coding gene Chr4:67463166-67665769 (-)



Homology
more
  • Human Ortholog
    BRINP1, BMP/retinoic acid inducible neural specific 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BRINP1, BMP/retinoic acid inducible neural specific 1
  • Synonyms
    DBC1, DBCCR1, FAM5A
  • Links
    NCBI Gene ID: 1620
    neXtProt AC: NX_O60477
    UniProt: O60477

  • Chr Location
    9q33.1
Human Diseases
more
  • Diseases
    2 with Brinp1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show increased adult neurogenesis in the subgranular zone of the dentate gyrus, altered neuronal differentiation in the hippocampus, and behavioral anomalies such as hyperactivity, reduced anxiety-like behaviors, poor social interaction, and a slight deficit in working memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    868
  • Tissues
    20
  • cDNA Data
    23
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028351 Ensembl Gene Model | MGI Sequence Detail 192884 C57BL/6J ±  kb
    transcript ENSMUST00000030036 Ensembl | MGI Sequence Detail 3212 Not Applicable  
    polypeptide ENSMUSP00000030036 Ensembl | MGI Sequence Detail 760 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000006291 BMP/retinoic acid-inducible neural-specific protein 1
      (term hierarchy)
    • InterPro Domains
      IPR033237 BMP/retinoic acid-inducible neural-specific protein
      IPR020864 Membrane attack complex component/perforin (MACPF) domain
    • GlyGen
      Q920P3 8 sites, 10 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 23
      Primer pair 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 10
      Phenotypes 5
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:339532 Li J, et al., Integrative genomic analysis of early neurogenesis reveals a temporal genetic program for differentiation and specification of preplate and Cajal-Retzius neurons. PLoS Genet. 2021 Mar;17(3):e1009355
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory