Hspb3 MGI Mouse Gene Detail - MGI:1928479

Symbol

Hspb3
Name

heat shock protein 3
Synonyms

2310035K17Rik, 27kDa, spb3

Feature Type

protein coding gene
IDs

MGI:1928479
NCBI Gene: 56534
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr13:113799432-113800212 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 64.01 cM
Mapping Data

2 experiments

SNPs within 2kb

104 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928479	protein coding gene	Chr13:113799432-113800212 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020953	protein coding gene	Chr13:116315287-116316067 (-)
A/J	MGP_AJ_G0020903	protein coding gene	Chr13:111663792-111664572 (-)
AKR/J	MGP_AKRJ_G0020878	protein coding gene	Chr13:115003414-115004194 (-)
BALB/cJ	MGP_BALBcJ_G0020903	protein coding gene	Chr13:112338987-112339767 (-)
C3H/HeJ	MGP_C3HHeJ_G0020692	protein coding gene	Chr13:114801380-114802160 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021339	protein coding gene	Chr13:119745110-119745890 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018908	protein coding gene	Chr13:106910274-106911053 (-)
CAST/EiJ	MGP_CASTEiJ_G0020211	protein coding gene	Chr13:114450875-114451655 (-)
CBA/J	MGP_CBAJ_G0020654	protein coding gene	Chr13:124353258-124354038 (-)
DBA/2J	MGP_DBA2J_G0020777	protein coding gene	Chr13:111345585-111346365 (-)
FVB/NJ	MGP_FVBNJ_G0020761	protein coding gene	Chr13:110028331-110029111 (-)
LP/J	MGP_LPJ_G0020853	protein coding gene	Chr13:116343632-116344412 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020789	protein coding gene	Chr13:124610306-124611086 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021375	protein coding gene	Chr13:114493033-114493813 (-)
PWK/PhJ	MGP_PWKPhJ_G0019965	protein coding gene	Chr13:110114990-110115770 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019786	protein coding gene	Chr13:110797381-110798158 (-)
WSB/EiJ	MGP_WSBEiJ_G0020269	protein coding gene	Chr13:115076439-115077219 (-)

Human Ortholog

HSPB3, heat shock protein family B (small) member 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSPB3, heat shock protein family B (small) member 3
Synonyms

DHMN2C, HMN2C, HMND4, HSPL27
Links

HGNC:5248

NCBI Gene ID: 8988

neXtProt AC: NX_Q12988

UniProt: Q12988
Chr Location

5q11.2; chr5:54455699-54456377 (+) GRCh38

MGI Vertebrate Homology

Hspb3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HSPB3
Gene Tree

Hspb3

Diseases

1 with human HSPB3 associations

				Human Disease	Mouse Models
				autosomal dominant distal hereditary motor neuronopathy 4 IDs autosomal dominant distal hereditary motor neuronopathy 4 DOID:0111209 OMIM:613376

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Targeted

2
Find Mice (IMSR)

4 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

855
Tissues

30
cDNA Data

5
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hspb3

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS26785.1

Ensembl

ENSMUSG00000051456 (Evidence)
NCBI Gene

56534

			Length	Strain/Species	Flank
genomic	56534	NCBI Gene Model \| MGI Sequence Detail	781	C57BL/6J	± kb
transcript	NM_019960	RefSeq \| MGI Sequence Detail	781	C57BL/6
polypeptide	Q9QZ57	UniProt \| EBI \| MGI Sequence Detail	154	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008817 heat shock protein beta-3

(term hierarchy)
InterPro Domains

IPR002068 Alpha crystallin/Hsp20 domain

IPR001436 Alpha crystallin/Small heat shock protein, animal type

IPR033894 Heat shock protein beta-3

IPR008978 HSP20-like chaperone

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All nucleic 5

cDNA 5

Microarray probesets 3

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MGI:1916838, MGI:2145297

Summaries

All 33

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hspb3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124124	Chr13:113800206-113800217 (-)	0 bp
Tssr124123	Chr13:113800187-113800198 (-)	19 bp
Tssr124122	Chr13:113800172-113800185 (-)	33 bp
Tssr124121	Chr13:113800147-113800170 (-)	53 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24