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Gpr37l1 Gene Detail
Summary
  • Symbol
    Gpr37l1
  • Name
    G protein-coupled receptor 37-like 1
  • Synonyms
    CAG-18, D0Kist8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928503
    NCBI Gene: 171469
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:135087988-135095419 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 58.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    257 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928503
 protein coding gene Chr1:135087972-135095419 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016518
 protein coding gene Chr1:138901489-138908933 (-)
A/J MGP_AJ_G0016501
 protein coding gene Chr1:133653665-133661142 (-)
AKR/J MGP_AKRJ_G0016466
 protein coding gene Chr1:137630058-137637540 (-)
BALB/cJ MGP_BALBcJ_G0016461
 protein coding gene Chr1:133967590-133974994 (-)
C3H/HeJ MGP_C3HHeJ_G0016287
 protein coding gene Chr1:137728024-137735467 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016922
 protein coding gene Chr1:143925326-143934609 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014633
 protein coding gene Chr1:126763776-126771206 (-)
CAST/EiJ MGP_CASTEiJ_G0015867
 protein coding gene Chr1:136798316-136805695 (-)
CBA/J MGP_CBAJ_G0016260
 protein coding gene Chr1:148895017-148905374 (-)
DBA/2J MGP_DBA2J_G0016366
 protein coding gene Chr1:132655685-132663527 (-)
FVB/NJ MGP_FVBNJ_G0016365
 protein coding gene Chr1:131292767-131300511 (-)
LP/J MGP_LPJ_G0016437
 protein coding gene Chr1:140143591-140151013 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016390
 protein coding gene Chr1:154587227-154594680 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016958
 protein coding gene Chr1:137379183-137386633 (-)
PWK/PhJ MGP_PWKPhJ_G0015653
 protein coding gene Chr1:131678340-131685758 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015440
 protein coding gene Chr1:136345701-136353149 (-)
WSB/EiJ MGP_WSBEiJ_G0015930
 protein coding gene Chr1:137411672-137419808 (-)



Homology
more
  • Human Ortholog
    GPR37L1, G protein-coupled receptor 37 like 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR37L1, G protein-coupled receptor 37 like 1
  • Synonyms
    ET(B)R-LP-2, ETBR-LP-2, ETBRLP2
  • Links
    NCBI Gene ID: 9283
    neXtProt AC: NX_O60883
    UniProt: O60883

  • Chr Location
    1q32.1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 4 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele may exhibit no abnormal phenotype, precocious cerebellum development and improved motor functions or abnormal blood pressure in female mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    27
  • cDNA Data
    13
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 171469 NCBI Gene Model | MGI Sequence Detail 7432 C57BL/6J ±  kb
    transcript NM_134438 RefSeq | MGI Sequence Detail 2267 C57BL/6  
    polypeptide Q99JG2 UniProt | EBI | MGI Sequence Detail 481 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000001112 G-protein coupled receptor 37-like 1
      (term hierarchy)
    • InterPro Domains
      IPR017452 GPCR, rhodopsin-like, 7TM
      IPR003909 G protein-coupled receptor 37 orphan
      IPR000276 G protein-coupled receptor, rhodopsin-like
    • GlyGen
      Q99JG2 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37477, MGI:108433, MGI:2138545
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 26
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:347898 Bang S, et al., Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis. J Clin Invest. 2024 Mar 26;134(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory