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Slc4a8 Gene Detail
Summary
  • Symbol
    Slc4a8
  • Name
    solute carrier family 4 (anion exchanger), member 8
  • Synonyms
    KNBC-3, NDCBE, sodium bicarbonate cotransporter isoform 3 kNBC-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928745
    NCBI Gene: 59033
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:100659628-100721849 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.39 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1998 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928745
 protein coding gene Chr15:100659628-100721852 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022361
 protein coding gene Chr15:102753305-102817559 (+)
A/J MGP_AJ_G0022323
 protein coding gene Chr15:98704015-98761827 (+)
AKR/J MGP_AKRJ_G0022299
 protein coding gene Chr15:101724528-101778559 (+)
BALB/cJ MGP_BALBcJ_G0022327
 protein coding gene Chr15:98814354-98869266 (+)
C3H/HeJ MGP_C3HHeJ_G0022097
 protein coding gene Chr15:101810665-101868107 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022775
 protein coding gene Chr15:106609652-106667250 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020300
 protein coding gene Chr15:94456210-94518750 (+)
CAST/EiJ MGP_CASTEiJ_G0021622
 protein coding gene Chr15:102641803-102706683 (+)
CBA/J MGP_CBAJ_G0022066
 protein coding gene Chr15:110269324-110334411 (+)
DBA/2J MGP_DBA2J_G0022193
 protein coding gene Chr15:98054215-98107977 (+)
FVB/NJ MGP_FVBNJ_G0022172
 protein coding gene Chr15:97087989-97147676 (+)
LP/J MGP_LPJ_G0022264
 protein coding gene Chr15:102906936-102965803 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022193
 protein coding gene Chr15:113985628-114045547 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022789
 protein coding gene Chr15:101728211-101785913 (+)
PWK/PhJ MGP_PWKPhJ_G0021361
 protein coding gene Chr15:98191174-98250156 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021193
 protein coding gene Chr15:101629816-101686476 (+)
WSB/EiJ MGP_WSBEiJ_G0021672
 protein coding gene Chr15:102351159-102409454 (+)



Homology
more
  • Human Ortholog
    SLC4A8, solute carrier family 4 member 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC4A8, solute carrier family 4 member 8
  • Synonyms
    NBC3, NDCBE
  • Links
    NCBI Gene ID: 9498
    neXtProt AC: NX_Q2Y0W8
    UniProt: Q2Y0W8

  • Chr Location
    12q13.13; chr12:51391317-51515763 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal sodium and chloride ion excretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    926
  • Tissues
    145
  • cDNA Data
    43
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023032 Ensembl Gene Model | MGI Sequence Detail 62222 C57BL/6J ±  kb
    transcript ENSMUST00000023776 Ensembl | MGI Sequence Detail 11790 Not Applicable  
    polypeptide ENSMUSP00000023776 Ensembl | MGI Sequence Detail 1089 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000015163 electroneutral sodium bicarbonate exchanger 1
      (term hierarchy)
    • InterPro Domains
      IPR013769 Band 3 cytoplasmic domain
      IPR003020 Bicarbonate transporter, eukaryotic
      IPR011531 Bicarbonate transporter-like, transmembrane domain
      IPR016152 Phosphotransferase/anion transporter
      IPR003024 Sodium bicarbonate cotransporter
    • GlyGen
      Q8JZR6 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 45
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2146219
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 11
      Phenotypes 35
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:346895 Guo P, et al., A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis. Elife. 2024 Feb 12;13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory