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Rab2a Gene Detail
Summary
  • Symbol
    Rab2a
  • Name
    RAB2A, member RAS oncogene family
  • Synonyms
    9330148M11Rik, Rab2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928750
    NCBI Gene: 59021
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:8535661-8607708 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 3.63 cM, cytoband A1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1813 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928750
 protein coding gene Chr4:8535644-8607778 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028039
 protein coding gene Chr4:5105771-5184654 (+)
A/J MGP_AJ_G0027997
 protein coding gene Chr4:5014591-5087470 (+)
AKR/J MGP_AKRJ_G0027963
 protein coding gene Chr4:5043548-5122115 (+)
BALB/cJ MGP_BALBcJ_G0028009
 protein coding gene Chr4:4993832-5068341 (+)
C3H/HeJ MGP_C3HHeJ_G0027739
 protein coding gene Chr4:5211038-5285855 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028452
 protein coding gene Chr4:5409987-5484363 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025796
 protein coding gene Chr4:4708967-4782457 (+)
CAST/EiJ MGP_CASTEiJ_G0027193
 protein coding gene Chr4:5052721-5131038 (+)
CBA/J MGP_CBAJ_G0027714
 protein coding gene Chr4:5491810-5575730 (+)
DBA/2J MGP_DBA2J_G0027854
 protein coding gene Chr4:4980450-5055515 (+)
FVB/NJ MGP_FVBNJ_G0027821
 protein coding gene Chr4:4844399-4920515 (+)
LP/J MGP_LPJ_G0027965
 protein coding gene Chr4:5122247-5200693 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027854
 protein coding gene Chr4:5731698-5809459 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028511
 protein coding gene Chr4:5041559-5115168 (+)
PWK/PhJ MGP_PWKPhJ_G0026914
 protein coding gene Chr4:4976054-5048732 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026744
 protein coding gene Chr4:4997611-5070246 (+)
WSB/EiJ MGP_WSBEiJ_G0027272
 protein coding gene Chr4:5139295-5216146 (+)



Homology
more
  • Human Ortholog
    RAB2A, RAB2A, member RAS oncogene family
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAB2A, RAB2A, member RAS oncogene family
  • Synonyms
    LHX, RAB2
  • Links
    NCBI Gene ID: 5862
    neXtProt AC: NX_P61019
    UniProt: P61019

  • Chr Location
    8q12.1-q12.2; chr8:60516910-60623644 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    8
  • cDNA Data
    155
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 59021 NCBI Gene Model | MGI Sequence Detail 72048 C57BL/6J ±  kb
    transcript NM_001411828 RefSeq | MGI Sequence Detail 2300 C57BL/6  
    polypeptide P53994 UniProt | EBI | MGI Sequence Detail 212 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013603 Ras-related protein Rab-2A
      (term hierarchy)
    • EC
      3.6.5.2
    • InterPro Domains
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR050209 Rab GTPases family involved in membrane trafficking
      IPR001806 Small GTPase
      IPR005225 Small GTP-binding protein domain
    • GlyGen
      P53994 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 156
      cDNA 155
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1915381, MGI:2135555
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:350937 Wang H, et al., Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads. PLoS Genet. 2024 Jun;20(6):e1011337
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory