Pfdn5 MGI Mouse Gene Detail - MGI:1928753

Symbol

Pfdn5
Name

prefoldin 5
Synonyms

1190001O17Rik, 1700010A06Rik, c-myc binding protein MM-1, D15Ertd697e, EIG-1, MM-1

Feature Type

protein coding gene
IDs

MGI:1928753
NCBI Gene: 56612
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:102234551-102239925 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 57.48 cM
Mapping Data

3 experiments

SNPs within 2kb

250 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928753	protein coding gene	Chr15:102234551-102240308 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022408	protein coding gene	Chr15:104497048-104502306 (+)
A/J	MGP_AJ_G0022370	protein coding gene	Chr15:100386008-100391556 (+)
AKR/J	MGP_AKRJ_G0022345	protein coding gene	Chr15:103427352-103435011 (+)
BALB/cJ	MGP_BALBcJ_G0022374	protein coding gene	Chr15:100431971-100437255 (+)
C3H/HeJ	MGP_C3HHeJ_G0022141	protein coding gene	Chr15:103502389-103507668 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022823	protein coding gene	Chr15:108379247-108386405 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020346	protein coding gene	Chr15:96160068-96165727 (+)
CAST/EiJ	MGP_CASTEiJ_G0021667	protein coding gene	Chr15:104373809-104379137 (+)
CBA/J	MGP_CBAJ_G0022110	protein coding gene	Chr15:112187130-112195329 (+)
DBA/2J	MGP_DBA2J_G0022241	protein coding gene	Chr15:99674591-99679907 (+)
FVB/NJ	MGP_FVBNJ_G0022217	protein coding gene	Chr15:98736529-98742467 (+)
LP/J	MGP_LPJ_G0022310	protein coding gene	Chr15:104653632-104658981 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022239	protein coding gene	Chr15:115752224-115757537 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022835	protein coding gene	Chr15:103452307-103460316 (+)
PWK/PhJ	MGP_PWKPhJ_G0021407	protein coding gene	Chr15:99830047-99835457 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021239	protein coding gene	Chr15:103306872-103311772 (+)
WSB/EiJ	MGP_WSBEiJ_G0021717	protein coding gene	Chr15:104085384-104090712 (+)

Human Ortholog

PFDN5, prefoldin subunit 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PFDN5, prefoldin subunit 5
Synonyms

MM-1, MM1, PFD5
Links

HGNC:8869

NCBI Gene ID: 5204

neXtProt AC: NX_Q99471

UniProt: Q99471
Chr Location

12q13.13; chr12:53295291-53299452 (+) GRCh38

MGI Vertebrate Homology

Pfdn5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PFDN5
Gene Tree

Pfdn5

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References

1 with disease annotations

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Phenotype Summary

40 phenotypes from 2 alleles in 2 genetic backgrounds
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (ENU)

1
Chemically induced (other)

1
Gene trapped

8
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Pfdn5
Incidental Mutations

APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced mutation exhibit photoreceptor degeneration, central nervous system abnormalities, and male infertility.

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All GO Annotations

25
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

741
Tissues

19
cDNA Data

214
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pfdn5

ZFIN pfdn5

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All Sequences

59
RefSeq

2
UniProt

8
CCDS

CCDS37227.1

Ensembl

ENSMUSG00000001289 (Evidence)
NCBI Gene

56612

			Length	Strain/Species	Flank
genomic	56612	NCBI Gene Model \| MGI Sequence Detail	5375	C57BL/6J	± kb
transcript	NM_027044	RefSeq \| MGI Sequence Detail	708	Not Specified
polypeptide	Q9WU28	UniProt \| EBI \| MGI Sequence Detail	154	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000012575 prefoldin subunit 5

(term hierarchy)
InterPro Domains

IPR009053 Prefoldin

IPR004127 Prefoldin alpha-like

IPR011599 Prefoldin alpha subunit, archaea-type

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All nucleic 215

cDNA 214

Primer pair 1

Microarray probesets 5

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MGI:1277126, MGI:1913474, MGI:1916585

Summaries

All 64

Developmental Gene Expression 2

Diseases 1

Gene Ontology 5

Phenotypes 31
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pfdn5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133374	Chr15:102234567-102234587 (+)	26 bp
Tssr133375	Chr15:102234590-102234606 (+)	47 bp
Tssr133376	Chr15:102234607-102234616 (+)	61 bp
Tssr133377	Chr15:102234804-102234822 (+)	262 bp
Tssr133378	Chr15:102234835-102234864 (+)	299 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24