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Scube2 Gene Detail
Summary
  • Symbol
    Scube2
  • Name
    signal peptide, CUB domain, EGF-like 2
  • Synonyms
    4932442O19Rik, Cegf1, ICRFP703B1614Q5.1, ICRFP703N2430Q5.1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928765
    NCBI Gene: 56788
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:109397897-109464886 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 57.53 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2022 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928765
 protein coding gene Chr7:109397883-109464886 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032849
 protein coding gene Chr7:113248702-113316852 (-)
A/J MGP_AJ_G0032833
 protein coding gene Chr7:110443580-110511330 (-)
AKR/J MGP_AKRJ_G0032764
 protein coding gene Chr7:113217998-113284795 (-)
BALB/cJ MGP_BALBcJ_G0032837
 protein coding gene Chr7:110142655-110210613 (-)
C3H/HeJ MGP_C3HHeJ_G0032547
 protein coding gene Chr7:113252921-113320700 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033343
 protein coding gene Chr7:117942862-118017792 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030316
 protein coding gene Chr7:112011266-112080464 (-)
CAST/EiJ MGP_CASTEiJ_G0031875
 protein coding gene Chr7:104767484-104853796 (-)
CBA/J MGP_CBAJ_G0032520
 protein coding gene Chr7:121812688-121878687 (-)
DBA/2J MGP_DBA2J_G0032672
 protein coding gene Chr7:108554442-108620961 (-)
FVB/NJ MGP_FVBNJ_G0032625
 protein coding gene Chr7:108408574-108474456 (-)
LP/J MGP_LPJ_G0032766
 protein coding gene Chr7:114776979-114849374 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032657
 protein coding gene Chr7:123458379-123531768 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033364
 protein coding gene Chr7:112230182-112296497 (-)
PWK/PhJ MGP_PWKPhJ_G0031582
 protein coding gene Chr7:101356458-101426013 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031430
 protein coding gene Chr7:98915159-98989134 (-)
WSB/EiJ MGP_WSBEiJ_G0031988
 protein coding gene Chr7:113070575-113140566 (-)



Homology
more
  • Human Ortholog
    SCUBE2, signal peptide, CUB domain and EGF like domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCUBE2, signal peptide, CUB domain and EGF like domain containing 2
  • Synonyms
    CEGB1, CEGF1, CEGP1, scube/You
  • Links
    NCBI Gene ID: 57758
    neXtProt AC: NX_Q9NQ36
    UniProt: Q9NQ36

  • Chr Location
    11p15.4; chr11:9019476-9138114 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation are smaller than controls. Mice also exhibit defective endochondral bone formation and impaired Ihh-mediated chondrocyte differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    879
  • Tissues
    107
  • cDNA Data
    12
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56788 NCBI Gene Model | MGI Sequence Detail 66990 C57BL/6J ±  kb
    transcript NM_020052 RefSeq | MGI Sequence Detail 3576 ZRU/MplStud  
    polypeptide Q9JJS0 UniProt | EBI | MGI Sequence Detail 997 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000031799 signal peptide, CUB and EGF-like domain-containing protein 2
      (term hierarchy)
    • InterPro Domains
      IPR026823 Complement Clr-like EGF domain
      IPR000859 CUB domain
      IPR024731 EGF domain
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR049883 NOTCH1 EGF-like calcium-binding domain
      IPR052071 Signal peptide, CUB and EGF-like domain-containing protein
      IPR035914 Spermadhesin, CUB domain superfamily
      IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
    • GlyGen
      Q9JJS0 7 sites, 4 N-linked glycans (6 sites)
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 12
      Primer pair 1
      Other 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1921671
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 8
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:306541 Lin YC, et al., SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling. Am J Hum Genet. 2021 Jan 7;108(1):115-133
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory