Isg20 MGI Mouse Gene Detail - MGI:1928895 - interferon-stimulated protein

Symbol

Isg20
Name

interferon-stimulated protein
Synonyms

1600023I01Rik, 2010107M23Rik, 20kDa, DnaQl, HEM45

Feature Type

protein coding gene
IDs

MGI:1928895
NCBI Gene: 57444
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr7:78563172-78570144 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 44.84 cM
Mapping Data

1 experiment

SNPs within 2kb

277 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928895	protein coding gene	Chr7:78561136-78570144 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032382	protein coding gene	Chr7:80751828-80758819 (+)
A/J	MGP_AJ_G0032361	protein coding gene	Chr7:78912099-78919076 (+)
AKR/J	MGP_AKRJ_G0032297	protein coding gene	Chr7:80598922-80605898 (+)
BALB/cJ	MGP_BALBcJ_G0032373	protein coding gene	Chr7:78613049-78620025 (+)
C3H/HeJ	MGP_C3HHeJ_G0032086	protein coding gene	Chr7:81263014-81269997 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032865	protein coding gene	Chr7:83931216-83938188 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029873	protein coding gene	Chr7:81466097-81473065 (+)
CAST/EiJ	MGP_CASTEiJ_G0031414	protein coding gene	Chr7:72109487-72116464 (+)
CBA/J	MGP_CBAJ_G0032052	protein coding gene	Chr7:86726790-86733771 (+)
DBA/2J	MGP_DBA2J_G0032207	protein coding gene	Chr7:77499783-77506764 (+)
FVB/NJ	MGP_FVBNJ_G0032162	protein coding gene	Chr7:77401591-77408565 (+)
LP/J	MGP_LPJ_G0032288	protein coding gene	Chr7:81999130-82006106 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032199	protein coding gene	Chr7:86966415-86973391 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032883	protein coding gene	Chr7:80040828-80047804 (+)
PWK/PhJ	MGP_PWKPhJ_G0031134	protein coding gene	Chr7:70646432-70653394 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030975	protein coding gene	Chr7:67024046-67030988 (+)
WSB/EiJ	MGP_WSBEiJ_G0031532	protein coding gene	Chr7:80369031-80376022 (+)

Human Ortholog

ISG20, interferon stimulated exonuclease gene 20

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ISG20, interferon stimulated exonuclease gene 20
Synonyms

CD25, HEM45
Links

HGNC:6130

NCBI Gene ID: 3669

neXtProt AC: NX_Q96AZ6

UniProt: Q96AZ6
Chr Location

15q26.1; chr15:88635632-88656483 (+) GRCh38

MGI Vertebrate Homology

Isg20 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ISG20
Gene Tree

Isg20

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Isg20
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice with loss of expression in renal tubules display increased susceptibility to kidney reperfusion injury.

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All GO Annotations

37
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

52
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN isg20

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All Sequences

63
RefSeq

16
UniProt

4
CCDS

CCDS21376.1, CCDS71982.1

Ensembl

ENSMUSG00000039236 (Evidence)
NCBI Gene

57444

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039236	Ensembl Gene Model \| MGI Sequence Detail	6973	C57BL/6J	± kb
transcript	ENSMUST00000121645	Ensembl \| MGI Sequence Detail	1087	Not Applicable
polypeptide	ENSMUSP00000112621	Ensembl \| MGI Sequence Detail	300	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009114 interferon-stimulated gene 20 kDa protein

(term hierarchy)
EC

3.1.13.1
InterPro Domains

IPR013520 Exonuclease, RNase T/DNA polymerase III

IPR012337 Ribonuclease H-like superfamily

IPR036397 Ribonuclease H superfamily

IPR047021 RNA exonuclease REXO1/REXO3/REXO4-like

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All nucleic 53

cDNA 53

Microarray probesets 3

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MGI:1914966, MGI:1923946

Summaries

All 46

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 17
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Isg20:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr67309	Chr7:78563149-78563176 (+)	-9 bp
Tssr67310	Chr7:78563184-78563196 (+)	18 bp
Tssr67311	Chr7:78563534-78563539 (+)	365 bp
Tssr67312	Chr7:78563542-78563612 (+)	405 bp
Tssr67313	Chr7:78563639-78563650 (+)	473 bp
Tssr67314	Chr7:78563657-78563666 (+)	490 bp
Tssr67315	Chr7:78563674-78563697 (+)	514 bp
Tssr67316	Chr7:78563699-78563739 (+)	547 bp
Tssr67317	Chr7:78563758-78563769 (+)	592 bp
Tssr67318	Chr7:78563964-78564042 (+)	831 bp
Tssr67319	Chr7:78564062-78564082 (+)	900 bp
Tssr67320	Chr7:78564274-78564283 (+)	1,107 bp
Tssr67321	Chr7:78566402-78566436 (+)	3,247 bp
Tssr67322	Chr7:78569876-78569888 (+)	6,710 bp
Tssr67323	Chr7:78569894-78569905 (+)	6,728 bp
Tssr67324	Chr7:78569922-78569946 (+)	6,762 bp
Tssr67325	Chr7:78569962-78569982 (+)	6,800 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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