About   Help   FAQ
Tacc2 Gene Detail
Summary
  • Symbol
    Tacc2
  • Name
    transforming, acidic coiled-coil containing protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928899
    NCBI Gene: 57752
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:130179168-130366515 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 73.19 cM, cytoband F4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6134 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928899
 protein coding gene Chr7:130154735-130369435 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033093
 protein coding gene Chr7:135100510-135311883 (+)
A/J MGP_AJ_G0033075
 protein coding gene Chr7:131423902-131613109 (+)
AKR/J MGP_AKRJ_G0033007
 protein coding gene Chr7:134907540-135113856 (+)
BALB/cJ MGP_BALBcJ_G0033076
 protein coding gene Chr7:131100995-131308715 (+)
C3H/HeJ MGP_C3HHeJ_G0032790
 protein coding gene Chr7:134780213-134981042 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033586
 protein coding gene Chr7:140309681-140509251 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030558
 protein coding gene Chr7:132560632-132771043 (+)
CAST/EiJ MGP_CASTEiJ_G0032120
 protein coding gene Chr7:126590647-126788788 (+)
CBA/J MGP_CBAJ_G0032763
 protein coding gene Chr7:145077950-145311745 (+)
DBA/2J MGP_DBA2J_G0032915
 protein coding gene Chr7:129428475-129619644 (+)
FVB/NJ MGP_FVBNJ_G0032868
 protein coding gene Chr7:129277282-129470631 (+)
LP/J MGP_LPJ_G0033009
 protein coding gene Chr7:136582091-136788129 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032900
 protein coding gene Chr7:146065355-146266955 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033605
 protein coding gene Chr7:133848772-134091856 (+)
PWK/PhJ MGP_PWKPhJ_G0031826
 protein coding gene Chr7:122486922-122686826 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031672
 protein coding gene Chr7:120666058-120858644 (+)
WSB/EiJ MGP_WSBEiJ_G0032231
 protein coding gene Chr7:134844960-135035605 (+)



Homology
more
  • Human Ortholog
    TACC2, transforming acidic coiled-coil containing protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TACC2, transforming acidic coiled-coil containing protein 2
  • Synonyms
    AZU-1, ECTACC
  • Links
    NCBI Gene ID: 10579
    neXtProt AC: NX_O95359
    UniProt: O95359

  • Chr Location
    10q26.13; chr10:121989163-122254545 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Homozygous null mice are healthy and fertile and do not display any increase in tumorigenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    76
  • cDNA Data
    42
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030852 Ensembl Gene Model | MGI Sequence Detail 187348 C57BL/6J ±  kb
transcript ENSMUST00000084513 Ensembl | MGI Sequence Detail 9029 Not Applicable  
polypeptide ENSMUSP00000081561 Ensembl | MGI Sequence Detail 2879 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    18 Sequences
  • Protein Ontology
    PR:000016007 transforming acidic coiled-coil-containing protein 2
    (term hierarchy)
  • InterPro Domains
    IPR039915 TACC family
    IPR007707 Transforming acidic coiled-coil-containing protein, C-terminal
  • GlyGen
    Q9JJG0 2 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 45
    cDNA 44
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 42
    Developmental Gene Expression 9
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory