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Stk4 Gene Detail
Summary
  • Symbol
    Stk4
  • Name
    serine/threonine kinase 4
  • Synonyms
    Kas-2, Mst1, sterile 20-like kinase 1, Ysk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929004
    NCBI Gene: 58231
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:163916033-163997444 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 84.60 cM, cytoband H3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2404 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929004
 protein coding gene Chr2:163912242-163997444 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026836
 protein coding gene Chr2:169449281-169547130 (+)
A/J MGP_AJ_G0026802
 protein coding gene Chr2:162594845-162679556 (+)
AKR/J MGP_AKRJ_G0026773
 protein coding gene Chr2:167411525-167502380 (+)
BALB/cJ MGP_BALBcJ_G0026811
 protein coding gene Chr2:162935069-163022223 (+)
C3H/HeJ MGP_C3HHeJ_G0026553
 protein coding gene Chr2:167763479-167856490 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027259
 protein coding gene Chr2:174394694-174481896 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024629
 protein coding gene Chr2:155903854-155990781 (+)
CAST/EiJ MGP_CASTEiJ_G0026014
 protein coding gene Chr2:168179040-168279202 (+)
CBA/J MGP_CBAJ_G0026530
 protein coding gene Chr2:180667236-180767642 (+)
DBA/2J MGP_DBA2J_G0026668
 protein coding gene Chr2:161764161-161849298 (+)
FVB/NJ MGP_FVBNJ_G0026634
 protein coding gene Chr2:160141240-160227480 (+)
LP/J MGP_LPJ_G0026771
 protein coding gene Chr2:169557424-169647453 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026656
 protein coding gene Chr2:184336070-184429491 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027315
 protein coding gene Chr2:167312460-167402737 (+)
PWK/PhJ MGP_PWKPhJ_G0025748
 protein coding gene Chr2:161337522-161427564 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025551
 protein coding gene Chr2:166191419-166277199 (+)
WSB/EiJ MGP_WSBEiJ_G0026084
 protein coding gene Chr2:168176712-168268214 (+)



Homology
more
  • Human Ortholog
    STK4, serine/threonine kinase 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STK4, serine/threonine kinase 4
  • Synonyms
    KRS2, MST1, YSK3
  • Links
    NCBI Gene ID: 6789
    neXtProt AC: NX_Q13043
    UniProt: Q13043

  • Chr Location
    20q13.12; chr20:44966494-45080021 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human STK4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 12 alleles in 14 genetic backgrounds
    69 phenotypes from multigenic genotypes
    117 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele have low numbers of nave T cells that are hyper-responsive to stimulation. Mice homozygous for knock-out alleles exhibit decreased peripheral T cell numbers due to impaired emigration and homing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    107
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    18
  • cDNA Data
    136
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 58231 NCBI Gene Model | MGI Sequence Detail 81412 C57BL/6J ±  kb
    transcript NM_021420 RefSeq | MGI Sequence Detail 5246 C57BL/6  
    polypeptide Q9JI11 UniProt | EBI | MGI Sequence Detail 487 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 136
      cDNA 136

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1203525, MGI:2138944, MGI:2139225
    References
    more
    • Summaries
      All 190
      Developmental Gene Expression 20
      Diseases 1
      Gene Ontology 22
      Phenotypes 117
    • Earliest
      J:29051 Bagrodia S, et al., Identification of a mouse p21Cdc42/Rac activated kinase [published erratum appears in J Biol Chem 1996 Jan 12;271(2):1250]. J Biol Chem. 1995 Sep 29;270(39):22731-7
    • Latest
      J:355261 Rehmani T, et al., SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP. Life Sci Alliance. 2024 Dec;7(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory