Fbxo3 MGI Mouse Gene Detail - MGI:1929084

Symbol

Fbxo3
Name

F-box protein 3
Synonyms

1200002G09Rik, 1700026K02Rik, Fba

Feature Type

protein coding gene
IDs

MGI:1929084
NCBI Gene: 57443
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:103858144-103893582 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 54.49 cM
Mapping Data

2 experiments

SNPs within 2kb

931 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929084	protein coding gene	Chr2:103858066-103893585 (+)
129S1/SvImJ	ENSMUSG00200002169	protein coding gene	Chr2:100668119-100703647 (+)
A/J	ENSMUSG00195000647	protein coding gene	Chr2:100837072-100871899 (+)
AKR/J	ENSMUSG00220001553	protein coding gene	Chr2:100587193-100622015 (+)
BALB/cJ	ENSMUSG00180020307	protein coding gene	Chr2:100638137-100672962 (+)
C3H/HeJ	ENSMUSG00175009860	protein coding gene	Chr2:100917468-100952999 (+)
C57BL/6NJ	ENSMUSG00215012022	protein coding gene	Chr2:100742115-100777636 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024022	protein coding gene	Chr2:97324232-97359925 (+)
CAST/EiJ	ENSTCUG00005001437	protein coding gene	Chr2:99997652-100032555 (+)
CBA/J	ENSMUSG00210002127	protein coding gene	Chr2:100915932-100950772 (+)
DBA/2J	ENSMUSG00185005520	protein coding gene	Chr2:100634973-100669797 (+)
FVB/NJ	ENSMUSG00205010790	protein coding gene	Chr2:99968532-100004047 (+)
JF1/MsJ	ENSUMUG00000020701	protein coding gene	Chr2:100327191-100361585 (+)
LP/J	ENSMUSG00230000783	protein coding gene	Chr2:102384300-102419122 (+)
NOD/ShiLtJ	ENSMUSG00190023313	protein coding gene	Chr2:100748630-100784148 (+)
NZO/HlLtJ	ENSMUSG00225007963	protein coding gene	Chr2:110290786-110326317 (+)
PWK/PhJ	ENSLUMG00010023817	protein coding gene	Chr2:100333587-100368056 (+)
SPRET/EiJ	ENSMSPG00010034727	protein coding gene	Chr2:102358024-102390117 (+)
WSB/EiJ	ENSIUOG00005001328	protein coding gene	Chr2:100433776-100469310 (+)

Human Ortholog

FBXO3, F-box protein 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBXO3, F-box protein 3
Synonyms

FBA, FBX3
Links

HGNC:13582

NCBI Gene ID: 26273

UniProt: Q9UK99
Chr Location

11p13; chr11:33740939-33774543 (-) GRCh38

MGI Vertebrate Homology

Fbxo3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FBXO3
Gene Tree

Fbxo3

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Fbxo3
Incidental Mutations

APF
Find Mice (IMSR)

24 strains or lines available

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All GO Annotations

23
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

24
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fbxo3

ZFIN fbxo3

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All Sequences

85
RefSeq

13
UniProt

4
CCDS

CCDS16484.1, CCDS16485.1, CCDS89529.1

Ensembl

ENSMUSG00000027180 (Evidence)
NCBI Gene

57443

			Length	Strain/Species	Flank
genomic	57443	NCBI Gene Model \| MGI Sequence Detail	35439	C57BL/6J	± kb
transcript	NM_212433	RefSeq \| MGI Sequence Detail	4659	Not Specified
polypeptide	Q9DC63	UniProt \| EBI \| MGI Sequence Detail	480	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000007400 F-box only protein 3

(term hierarchy)
InterPro Domains

IPR007474 ApaG domain

IPR036767 ApaG domain superfamily

IPR001810 F-box domain

IPR036047 F-box-like domain superfamily

IPR052121 F-box Protein Family Substrate Recognition Components

IPR018958 Knr4/Smi1-like domain

IPR037883 Knr4/Smi1-like domain superfamily

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All nucleic 26

cDNA 26

Microarray probesets 11

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MGI:1914700, MGI:1919505, MGI:2138830

Summaries

All 46

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 10
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fbxo3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19200	Chr2:103858102-103858125 (+)	-30 bp
Tssr19201	Chr2:103858168-103858213 (+)	47 bp
Tssr19202	Chr2:103872377-103872384 (+)	14,237 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24