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Sinhcaf Gene Detail
Summary
  • Symbol
    Sinhcaf
  • Name
    SIN3-HDAC complex associated factor
  • Synonyms
    Fam60a, Pptcs1, Tera
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929091
    NCBI Gene: 56306
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:148822538-148847968 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 78.67 cM, cytoband G3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    512 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929091
 protein coding gene Chr6:148822533-148847968 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031506
 protein coding gene Chr6:154031474-154062368 (-)
A/J MGP_AJ_G0031481
 protein coding gene Chr6:147915054-147942356 (-)
AKR/J MGP_AKRJ_G0031409
 protein coding gene Chr6:152334811-152362872 (-)
BALB/cJ MGP_BALBcJ_G0031489
 protein coding gene Chr6:147678361-147704023 (-)
C3H/HeJ MGP_C3HHeJ_G0031210
 protein coding gene Chr6:152389283-152418453 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031950
 protein coding gene Chr6:158118845-158133067 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029074
 protein coding gene Chr6:146640516-146663712 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0031170
 protein coding gene Chr6:164199424-164225070 (-)
DBA/2J MGP_DBA2J_G0031326
 protein coding gene Chr6:146714699-146735188 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0031412
 protein coding gene Chr6:154168271-154195277 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031318
 protein coding gene Chr6:167832946-167868623 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031983
 protein coding gene Chr6:152178123-152203709 (-)
PWK/PhJ MGP_PWKPhJ_G0030305
 protein coding gene Chr6:145226426-145252538 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030129
 protein coding gene Chr6:150290629-150309188 (-)
WSB/EiJ MGP_WSBEiJ_G0030672
 protein coding gene Chr6:152795238-152821199 (-)



Homology
more
  • Human Ortholog
    SINHCAF, SIN3-HDAC complex associated factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SINHCAF, SIN3-HDAC complex associated factor
  • Synonyms
    C12orf14, FAM60A, L4, TERA
  • Links
    NCBI Gene ID: 58516
    neXtProt AC: NX_Q9NP50
    UniProt: Q9NP50

  • Chr Location
    12p11.21; chr12:31280584-31327058 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit hypoplasia of visceral organs and die after E10.5 but before birth. Embryos exhibit growth retardation, cardiac defects, neural tube defects, gut rotation abnormalities, and incomplete lobulation of lungs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    20
  • cDNA Data
    121
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56306 NCBI Gene Model | MGI Sequence Detail 25431 C57BL/6J ±  kb
    transcript NM_001411261 RefSeq | MGI Sequence Detail 2953 C57BL/6  
    polypeptide Q8C8M1 UniProt | EBI | MGI Sequence Detail 221 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 127
      cDNA 121
      Primer pair 4
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1097676, MGI:6156409
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:42329 Saijoh Y, et al., Identification of putative downstream genes of Oct-3, a pluripotent cell-specific transcription factor. Genes Cells. 1996 Feb;1(2):239-52
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory