About   Help   FAQ
Uso1 Gene Detail
Summary
  • Symbol
    Uso1
  • Name
    USO1 vesicle docking factor
  • Synonyms
    TAP, transcytosis associated protein p115, Vdp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929095
    NCBI Gene: 56041
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:92285797-92350657 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 46.05 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1439 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929095
 protein coding gene Chr5:92285770-92350659 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029743
 protein coding gene Chr5:93297750-93368536 (+)
A/J MGP_AJ_G0029709
 protein coding gene Chr5:89599079-89664802 (+)
AKR/J MGP_AKRJ_G0029655
 protein coding gene Chr5:92526804-92599827 (+)
BALB/cJ MGP_BALBcJ_G0029719
 protein coding gene Chr5:90484807-90550450 (+)
C3H/HeJ MGP_C3HHeJ_G0029442
 protein coding gene Chr5:92933704-93001055 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030173
 protein coding gene Chr5:97009290-97074599 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027409
 protein coding gene Chr5:85239089-85311317 (+)
CAST/EiJ MGP_CASTEiJ_G0028852
 protein coding gene Chr5:92309610-92381040 (+)
CBA/J MGP_CBAJ_G0029412
 protein coding gene Chr5:100349339-100427571 (+)
DBA/2J MGP_DBA2J_G0029556
 protein coding gene Chr5:89645295-89710736 (+)
FVB/NJ MGP_FVBNJ_G0029515
 protein coding gene Chr5:88495480-88559963 (+)
LP/J MGP_LPJ_G0029644
 protein coding gene Chr5:93665832-93736497 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029544
 protein coding gene Chr5:105290860-105360630 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030207
 protein coding gene Chr5:92064537-92131872 (+)
PWK/PhJ MGP_PWKPhJ_G0028571
 protein coding gene Chr5:88705724-88772685 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028406
 protein coding gene Chr5:91427029-91492702 (+)
WSB/EiJ MGP_WSBEiJ_G0028931
 protein coding gene Chr5:92518817-92587878 (+)



Homology
more
  • Human Ortholog
    USO1, USO1 vesicle transport factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USO1, USO1 vesicle transport factor
  • Synonyms
    P115, TAP, VDP
  • Links
    NCBI Gene ID: 8615
    neXtProt AC: NX_O60763
    UniProt: O60763

  • Chr Location
    4q21.1; chr4:75724577-75814286 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 2 genetic backgrounds
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit embryonic lethality between E3.5 and E8.5 with disruption of Golgi apparatus in blastocyst cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    29
  • cDNA Data
    12
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029407 Ensembl Gene Model | MGI Sequence Detail 64861 C57BL/6J ±  kb
    transcript ENSMUST00000031355 Ensembl | MGI Sequence Detail 3898 Not Applicable  
    polypeptide ENSMUSP00000031355 Ensembl | MGI Sequence Detail 959 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000017144 general vesicular transport factor p115
      (term hierarchy)
    • InterPro Domains
      IPR000225 Armadillo
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR006955 Uso1/p115-like vesicle tethering protein, C-terminal
      IPR041209 Vesicle tethering protein p115, armadillo tether-repeat
      IPR006953 Vesicle tethering protein Uso1/P115-like, head domain
    • GlyGen
      Q9Z1Z0 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 3
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory