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Zbtb20 Gene Detail
Summary
  • Symbol
    Zbtb20
  • Name
    zinc finger and BTB domain containing 20
  • Synonyms
    1300017A20Rik, 7330412A13Rik, A930017C21Rik, D16Wsu73e, HOF, Zfp288
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929213
    NCBI Gene: 56490
  • Alliance
    gene page
  • Transcription Start Sites
    53 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:42728008-43462981 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 28.44 cM, cytoband B4
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12334 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929213
 protein coding gene Chr16:42696244-43462981 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022827
 protein coding gene Chr16:41558567-42322927 (+)
A/J MGP_AJ_G0022792
 protein coding gene Chr16:39659621-40415624 (+)
AKR/J MGP_AKRJ_G0022764
 protein coding gene Chr16:40979442-41727056 (+)
BALB/cJ MGP_BALBcJ_G0022793
 protein coding gene Chr16:39639572-40407918 (+)
C3H/HeJ MGP_C3HHeJ_G0022557
 protein coding gene Chr16:41183401-41911212 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023240
 protein coding gene Chr16:42523315-43303808 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020755
 protein coding gene Chr16:39761693-40489242 (+)
CAST/EiJ MGP_CASTEiJ_G0022083
 protein coding gene Chr16:41354769-42120792 (+)
CBA/J MGP_CBAJ_G0022528
 protein coding gene Chr16:44337826-45143032 (+)
DBA/2J MGP_DBA2J_G0022660
 protein coding gene Chr16:39405402-40141885 (+)
FVB/NJ MGP_FVBNJ_G0022635
 protein coding gene Chr16:39397534-40130976 (+)
LP/J MGP_LPJ_G0022728
 protein coding gene Chr16:41269644-42034229 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022654
 protein coding gene Chr16:43714298-44542260 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023255
 protein coding gene Chr16:40971710-41738191 (+)
PWK/PhJ MGP_PWKPhJ_G0021823
 protein coding gene Chr16:39810022-40554405 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021654
 protein coding gene Chr16:40897724-41640916 (+)
WSB/EiJ MGP_WSBEiJ_G0022127
 protein coding gene Chr16:41077336-41845518 (+)



Homology
more
  • Human Ortholog
    ZBTB20, zinc finger and BTB domain containing 20
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZBTB20, zinc finger and BTB domain containing 20
  • Synonyms
    DPZF, HOF, ODA-8S, PRIMS, ZNF288
  • Links
    NCBI Gene ID: 26137
    neXtProt AC: NX_Q9HC78
    UniProt: Q9HC78

  • Chr Location
    3q13.31; chr3:114314500-115147292 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 3 alleles in 3 genetic backgrounds
    32 phenotypes from multigenic genotypes
    310 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit growth retardation, disrupted homeostasis, and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1152
  • Tissues
    228
  • cDNA Data
    29
  • Literature Summary
    49
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56490 NCBI Gene Model | MGI Sequence Detail 734974 C57BL/6J ±  kb
    transcript NM_001393398 RefSeq | MGI Sequence Detail 26820 ZRU/MplStud  
    polypeptide Q8K0L9 UniProt | EBI | MGI Sequence Detail 741 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 29
      Primer pair 9
      Other 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-33985, MGI:106293, MGI:1915064, MGI:1925393, MGI:1925687, MGI:3057146
    References
    more
    • Summaries
      All 379
      Developmental Gene Expression 49
      Diseases 2
      Gene Ontology 9
      Phenotypes 310
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:354793 Kim TA, et al., Neural circuit mechanisms underlying aberrantly prolonged functional hyperemia in young Alzheimer's disease mice. Mol Psychiatry. 2024 Jul 24;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory