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Sae1 Gene Detail
Summary
  • Symbol
    Sae1
  • Name
    SUMO1 activating enzyme subunit 1
  • Synonyms
    2400010M20Rik, 2610044L12Rik, AOS1, D7Ertd177e, HSPC140, SUMO-1 activating enzyme subunit 1, Uble1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929264
    NCBI Gene: 56459
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:16054159-16121731 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 8.88 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1680 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929264
 protein coding gene Chr7:16054159-16121821 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031708
 protein coding gene Chr7:14020720-14089409 (-)
A/J MGP_AJ_G0031680
 protein coding gene Chr7:13798895-13859711 (-)
AKR/J MGP_AKRJ_G0031605
 protein coding gene Chr7:14117765-14179256 (-)
BALB/cJ MGP_BALBcJ_G0031687
 protein coding gene Chr7:13905801-13967917 (-)
C3H/HeJ MGP_C3HHeJ_G0031409
 protein coding gene Chr7:14297620-14364839 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032153
 protein coding gene Chr7:14771978-14836032 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029232
 protein coding gene Chr7:15351870-15412337 (-)
CAST/EiJ MGP_CASTEiJ_G0030760
 protein coding gene Chr7:11059385-11121964 (-)
CBA/J MGP_CBAJ_G0031368
 protein coding gene Chr7:15232576-15302807 (-)
DBA/2J MGP_DBA2J_G0031524
 protein coding gene Chr7:13683977-13746521 (-)
FVB/NJ MGP_FVBNJ_G0031480
 protein coding gene Chr7:13577275-13642897 (-)
LP/J MGP_LPJ_G0031609
 protein coding gene Chr7:14281938-14341805 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031515
 protein coding gene Chr7:15195495-15260829 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032182
 protein coding gene Chr7:13893716-13955932 (-)
PWK/PhJ MGP_PWKPhJ_G0030484
 protein coding gene Chr7:11206201-11268338 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030311
 protein coding gene Chr7:8808873-8868126 (-)
WSB/EiJ MGP_WSBEiJ_G0030857
 protein coding gene Chr7:13945352-14011099 (-)



Homology
more
  • Human Ortholog
    SAE1, SUMO1 activating enzyme subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAE1, SUMO1 activating enzyme subunit 1
  • Synonyms
    AOS1, HSPC140, SUA1, UBLE1A
  • Links
    NCBI Gene ID: 10055
    neXtProt AC: NX_Q9UBE0
    UniProt: Q9UBE0

  • Chr Location
    19q13.32; chr19:47113274-47210636 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    34
  • cDNA Data
    243
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052833 Ensembl Gene Model | MGI Sequence Detail 67573 C57BL/6J ±  kb
    transcript ENSMUST00000210999 Ensembl | MGI Sequence Detail 1254 Not Applicable  
    polypeptide ENSMUSP00000147409 Ensembl | MGI Sequence Detail 350 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 245
      cDNA 243
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1098682, MGI:1914236, MGI:1923788, MGI:2142107, MGI:2142274
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory