Ptges3 MGI Mouse Gene Detail - MGI:1929282 - prostaglandin E synthase 3

Symbol

Ptges3
Name

prostaglandin E synthase 3
Synonyms

5730442A20Rik, cPGES, p23 cochaperone, Ptges, sid3177, Tebp

Feature Type

protein coding gene
IDs

MGI:1929282
NCBI Gene: 56351
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr10:127894851-127913123 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 76.39 cM
Mapping Data

1 experiment

SNPs within 2kb

390 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929282	protein coding gene	Chr10:127894823-127913141 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017846	protein coding gene	Chr10:131732952-131752462 (+)
A/J	MGP_AJ_G0017821	protein coding gene	Chr10:126461241-126480301 (+)
AKR/J	MGP_AKRJ_G0017784	protein coding gene	Chr10:130183848-130210706 (+)
BALB/cJ	MGP_BALBcJ_G0017785	protein coding gene	Chr10:126845815-126864603 (+)
C3H/HeJ	MGP_C3HHeJ_G0017608	protein coding gene	Chr10:130341724-130360202 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018240	protein coding gene	Chr10:136226340-136230126 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015918	protein coding gene	Chr10:120425457-120442048 (+)
CAST/EiJ	MGP_CASTEiJ_G0017169	protein coding gene	Chr10:131048460-131067598 (+)
CBA/J	MGP_CBAJ_G0017578	protein coding gene	Chr10:141727121-141747957 (+)
DBA/2J	MGP_DBA2J_G0017684	protein coding gene	Chr10:125533846-125553646 (+)
FVB/NJ	MGP_FVBNJ_G0017679	protein coding gene	Chr10:124470222-124489218 (+)
LP/J	MGP_LPJ_G0017758	protein coding gene	Chr10:132348628-132368498 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017707	protein coding gene	Chr10:144346532-144353313 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018280	protein coding gene	Chr10:130276491-130295513 (+)
PWK/PhJ	MGP_PWKPhJ_G0016954	protein coding gene	Chr10:125783661-125804779 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016743	protein coding gene	Chr10:129359492-129377524 (+)
WSB/EiJ	MGP_WSBEiJ_G0017228	protein coding gene	Chr10:130502617-130509868 (+)

Human Ortholog

PTGES3, prostaglandin E synthase 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTGES3, prostaglandin E synthase 3
Synonyms

cPGES, P23, TEBP
Links

HGNC:16049

NCBI Gene ID: 10728

neXtProt AC: NX_Q15185

UniProt: Q15185
Chr Location

12q13.3; chr12:56663341-56688408 (-) GRCh38

MGI Vertebrate Homology

Ptges3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PTGES3
Gene Tree

Ptges3

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Phenotype Summary

22 phenotypes from 3 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

79
Endonuclease-mediated

1
Gene trapped

76
Targeted

2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Disruption of gene function results in neonatal lethality, respiratory system abnormalities, as well as skin morphological and physiological defects.

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All GO Annotations

59
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

741
Tissues

9
cDNA Data

144
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptges3

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All Sequences

49
RefSeq

2
UniProt

4
CCDS

CCDS36087.1

Ensembl

ENSMUSG00000071072 (Evidence)
NCBI Gene

56351

			Length	Strain/Species	Flank
genomic	56351	NCBI Gene Model \| MGI Sequence Detail	18273	C57BL/6J	± kb
transcript	NM_019766	RefSeq \| MGI Sequence Detail	1954	C57BL/6
polypeptide	Q9R0Q7	UniProt \| EBI \| MGI Sequence Detail	160	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013423 prostaglandin E synthase 3

(term hierarchy)
PDB

7Y04, 8H77
EC

5.3.99.3
InterPro Domains

IPR045250 Co-chaperone protein p23-like

IPR007052 CS domain

IPR008978 HSP20-like chaperone
GlyGen

Q9R0Q7 1 site, 1 O-linked glycan (1 site)

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All nucleic 145

cDNA 145

Microarray probesets 6

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MGI:1913886

Summaries

All 52

Developmental Gene Expression 5

Gene Ontology 9

Phenotypes 15
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:353907 Kantarci H, et al., Schwann cell-secreted PGE(2) promotes sensory neuron excitability during development. Cell. 2024 Aug 22;187(17):4690-4712.e30

TSS for Ptges3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96312	Chr10:127894816-127894829 (+)	-28 bp
Tssr96313	Chr10:127894843-127894894 (+)	18 bp
Tssr96314	Chr10:127894904-127894921 (+)	62 bp
Tssr96315	Chr10:127894933-127894952 (+)	92 bp
Tssr96316	Chr10:127894965-127895022 (+)	143 bp
Tssr96317	Chr10:127897209-127897213 (+)	2,360 bp
Tssr96318	Chr10:127904080-127904091 (+)	9,235 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24