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Adgrl1 Gene Detail
Summary
  • Symbol
    Adgrl1
  • Name
    adhesion G protein-coupled receptor L1
  • Synonyms
    2900070I05Rik, Lec2, lectomedin-2, Lphn1, mKIAA0821
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929461
    NCBI Gene: 330814
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:84626734-84668583 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 40.22 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    651 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929461
 protein coding gene Chr8:84626598-84668583 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033841
 protein coding gene Chr8:84760111-84801505 (+)
A/J MGP_AJ_G0033824
 protein coding gene Chr8:81442161-81483449 (+)
AKR/J MGP_AKRJ_G0033750
 protein coding gene Chr8:83843995-83885287 (+)
BALB/cJ MGP_BALBcJ_G0033817
 protein coding gene Chr8:81547617-81588872 (+)
C3H/HeJ MGP_C3HHeJ_G0033527
 protein coding gene Chr8:84459577-84501959 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034337
 protein coding gene Chr8:87984415-88033639 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031279
 protein coding gene Chr8:75239692-75281798 (+)
CAST/EiJ MGP_CASTEiJ_G0032857
 protein coding gene Chr8:83872663-83914104 (+)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0033658
 protein coding gene Chr8:81078712-81120059 (+)
FVB/NJ MGP_FVBNJ_G0033604
 protein coding gene Chr8:79999891-80041653 (+)
LP/J MGP_LPJ_G0033748
 protein coding gene Chr8:84869964-84915487 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033646
 protein coding gene Chr8:93635692-93676993 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034354
 protein coding gene Chr8:83822422-83865595 (+)
PWK/PhJ MGP_PWKPhJ_G0032561
 protein coding gene Chr8:80295978-80338491 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032398
 protein coding gene Chr8:82628486-82670066 (+)
WSB/EiJ MGP_WSBEiJ_G0032970
 protein coding gene Chr8:84231978-84273850 (+)



Homology
more
  • Human Ortholog
    ADGRL1, adhesion G protein-coupled receptor L1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADGRL1, adhesion G protein-coupled receptor L1
  • Synonyms
    CIRL1, CL1, DEDBANP, LEC2, LPHN1
  • Links
    NCBI Gene ID: 22859
    neXtProt AC: NX_O94910
    UniProt: O94910

  • Chr Location
    19p13.12; chr19:14147743-14206187 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null allele at this locus are viable and fertile. Female homozygotes fail adequately to care for their litters.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    33
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    791
  • Tissues
    44
  • cDNA Data
    16
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000013033 Ensembl Gene Model | MGI Sequence Detail 41850 C57BL/6J ±  kb
    transcript ENSMUST00000152978 Ensembl | MGI Sequence Detail 5734 Not Applicable  
    polypeptide ENSMUSP00000115295 Ensembl | MGI Sequence Detail 1516 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000001233 adhesion G protein-coupled receptor L1
      (term hierarchy)
    • PDB
      2JX9, 2JXA, 6SKA
    • InterPro Domains
      IPR000922 D-galactoside/L-rhamnose binding SUEL lectin domain
      IPR043159 D-galactoside/L-rhamnose binding SUEL lectin domain superfamily
      IPR032471 GAIN domain, N-terminal
      IPR046338 GAIN domain superfamily
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR003924 GPCR, family 2, latrophilin
      IPR003334 GPCR, family 2, latrophilin, C-terminal
      IPR017981 GPCR, family 2-like, 7TM
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR000203 GPS motif
      IPR031234 Latrophilin-1, , transmembrane domain
      IPR003112 Olfactomedin-like domain
      IPR050605 Olfactomedin-like domain-containing protein
    • GlyGen
      Q80TR1 9 sites, 8 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1914521, MGI:2142473
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 41
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:352327 Matus D, et al., Essential Role of Latrophilin-1 Adhesion GPCR Nanoclusters in Inhibitory Synapses. J Neurosci. 2024 Jun 5;44(23)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory