About   Help   FAQ
Arhgap35 Gene Detail
Summary
  • Symbol
    Arhgap35
  • Name
    Rho GTPase activating protein 35
  • Synonyms
    6430596G11Rik, Grlf1, p190A, p190RhoGAP, P190 RhoGAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929494
    NCBI Gene: 232906
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:16228398-16349313 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2275 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929494
 protein coding gene Chr7:16227644-16349313 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031712
 protein coding gene Chr7:14208277-14337287 (-)
A/J MGP_AJ_G0031684
 protein coding gene Chr7:13966575-14088140 (-)
AKR/J MGP_AKRJ_G0031609
 protein coding gene Chr7:14287510-14411562 (-)
BALB/cJ MGP_BALBcJ_G0031691
 protein coding gene Chr7:14077184-14200190 (-)
C3H/HeJ MGP_C3HHeJ_G0031413
 protein coding gene Chr7:14477422-14600198 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032157
 protein coding gene Chr7:14954782-15092777 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029236
 protein coding gene Chr7:15517244-15637927 (-)
CAST/EiJ MGP_CASTEiJ_G0030764
 protein coding gene Chr7:11237906-11358451 (-)
CBA/J MGP_CBAJ_G0031372
 protein coding gene Chr7:15428407-15557184 (-)
DBA/2J MGP_DBA2J_G0031528
 protein coding gene Chr7:13855683-13978453 (-)
FVB/NJ MGP_FVBNJ_G0031484
 protein coding gene Chr7:13752952-13882863 (-)
LP/J MGP_LPJ_G0031613
 protein coding gene Chr7:14457148-14585179 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031519
 protein coding gene Chr7:15375264-15502727 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032186
 protein coding gene Chr7:14066186-14191009 (-)
PWK/PhJ MGP_PWKPhJ_G0030488
 protein coding gene Chr7:11377751-11503663 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030315
 protein coding gene Chr7:8980975-9115471 (-)
WSB/EiJ MGP_WSBEiJ_G0030861
 protein coding gene Chr7:14127114-14249921 (-)



Homology
more
  • Human Ortholog
    ARHGAP35, Rho GTPase activating protein 35
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGAP35, Rho GTPase activating protein 35
  • Synonyms
    GRF-1, GRLF1, P190-A, P190A, p190ARhoGAP, p190RhoGAP
  • Links
    NCBI Gene ID: 2909
    neXtProt AC: NX_Q9NRY4
    UniProt: Q9NRY4

  • Chr Location
    19q13.32; chr19:46860997-47005077 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 3 alleles in 5 genetic backgrounds
    6 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene usually die within 2 days of birth and never survive beyond 3 weeks. Observed phenotypes include defects in eye morphogenesis, forebrain development, neural tube closure, axon guidance and fasciculation, and renal abnormalities, including hypoplastic and glomerulocystic kidneys, associated with a ciliogenesis defect.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    28
  • cDNA Data
    12
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 232906 NCBI Gene Model | MGI Sequence Detail 120916 C57BL/6J ±  kb
    transcript NM_172739 RefSeq | MGI Sequence Detail 8393 C57BL/6  
    polypeptide Q91YM2 UniProt | EBI | MGI Sequence Detail 1499 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000008262 Rho GTPase-activating protein 35
      (term hierarchy)
    • InterPro Domains
      IPR002713 FF domain
      IPR036517 FF domain superfamily
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR051978 Rho GTPase-activating domain-containing protein
      IPR000198 Rho GTPase-activating protein domain
      IPR032835 Rho GTPase-activating protein, FF domain
      IPR045786 Rho GTPase-activating protein, pG1 and pG2 domain
      IPR039007 Rho GTPase-activating protein, pG1 domain
      IPR039006 Rho GTPase-activating protein, pG2 domain
      IPR008936 Rho GTPase activation protein
      IPR001806 Small GTPase
    • GlyGen
      Q91YM2 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142039
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 12
      Gene Ontology 17
      Phenotypes 19
    • Earliest
      J:65296 Brouns MR, et al., The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development. Development. 2000 Nov;127(22):4891-903
    • Latest
      J:346646 Sharma R, et al., The CPLANE protein Fuzzy regulates ciliogenesis by suppressing actin polymerization at the base of the primary cilium via p190A RhoGAP. Development. 2024 Mar 15;151(6):dev202322
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory