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Mlst8 Gene Detail
Summary
  • Symbol
    Mlst8
  • Name
    MTOR associated protein, LST8 homolog (S. cerevisiae)
  • Synonyms
    0610033N12Rik, Gbl, mLST8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929514
    NCBI Gene: 56716
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24692525-24698052 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.39 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    173 from dbSNP Build 142
  • Strain Annotations
    31
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929514
 protein coding gene Chr17:24692524-24698722 (-)
129S1/SvImJ ENSMUSGG00200055001
 protein coding gene Chr17:20143564-20143744 (-)
129S1/SvImJ ENSMUSG00200052064
 protein coding gene Chr17:20138837-20143547 (-)
A/J ENSMUSG00195048604
 protein coding gene Chr17:21157665-21162375 (-)
A/J ENSMUSGG00195055531
 protein coding gene Chr17:21162392-21162572 (-)
AKR/J ENSMUSG00220024903
 protein coding gene Chr17:20204039-20208749 (-)
AKR/J ENSMUSGG00220054375
 protein coding gene Chr17:20208766-20208946 (-)
BALB/cJ ENSMUSG00180032776
 protein coding gene Chr17:20431264-20435974 (-)
BALB/cJ ENSMUSGG00180055606
 protein coding gene Chr17:20435991-20436171 (-)
C3H/HeJ ENSMUSGG00175055212
 protein coding gene Chr17:20194403-20194583 (-)
C3H/HeJ ENSMUSG00175048747
 protein coding gene Chr17:20189676-20194386 (-)
C57BL/6NJ ENSMUSG00215049585
 protein coding gene Chr17:20200500-20205210 (-)
C57BL/6NJ ENSMUSGG00215055836
 protein coding gene Chr17:20205227-20205407 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021187
 protein coding gene Chr17:20293578-20299123 (-)
CAST/EiJ ENSTCUG00005050137
 protein coding gene Chr17:20770670-20775378 (-)
CBA/J ENSMUSG00210035445
 protein coding gene Chr17:20028501-20033211 (-)
CBA/J ENSMUSGG00210054752
 protein coding gene Chr17:20033228-20033408 (-)
DBA/2J ENSMUSGG00185057979
 protein coding gene Chr17:22250725-22250905 (-)
DBA/2J ENSMUSG00185049791
 protein coding gene Chr17:22245998-22250708 (-)
FVB/NJ ENSMUSG00205050717
 protein coding gene Chr17:20497576-20502286 (-)
FVB/NJ ENSMUSGG00205054690
 protein coding gene Chr17:20502303-20502483 (-)
JF1/MsJ ENSUMUG00000056972
 protein coding gene Chr17:21692320-21697030 (-)
LP/J ENSMUSGG00230055902
 protein coding gene Chr17:23648232-23648412 (-)
LP/J ENSMUSG00230054477
 protein coding gene Chr17:23643505-23648215 (-)
NOD/ShiLtJ ENSMUSGG00190055148
 protein coding gene Chr17:20139474-20139654 (-)
NOD/ShiLtJ ENSMUSG00190048473
 protein coding gene Chr17:20134747-20139457 (-)
NZO/HlLtJ ENSMUSG00225050103
 protein coding gene Chr17:25565136-25569846 (-)
NZO/HlLtJ ENSMUSGG00225055731
 protein coding gene Chr17:25569863-25570043 (-)
PWK/PhJ ENSLUMG00010017355
 protein coding gene Chr17:19601456-19606166 (-)
SPRET/EiJ ENSMSPG00010045272
 protein coding gene Chr17:20938016-20942972 (-)
WSB/EiJ ENSIUOG00005048875
 protein coding gene Chr17:20883600-20888310 (-)



Homology
more
  • Human Ortholog
    MLST8, MTOR associated protein MLST8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MLST8, MTOR associated protein MLST8
  • Synonyms
    GbetaL, GBL, LST8, POP3, WAT1
  • Links
    NCBI Gene ID: 64223
    UniProt: Q9BVC4

  • Chr Location
    16p13.3; chr16:2204248-2209453 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation exhibit lethality around E10.5 and abnormal yolk sac vasculature, brain development and heart development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    628
  • Tissues
    30
  • cDNA Data
    19
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024142 Ensembl Gene Model | MGI Sequence Detail 5528 C57BL/6J ±  kb
    transcript ENSMUST00000179163 Ensembl | MGI Sequence Detail 3340 Not Applicable  
    polypeptide ENSMUSP00000136287 Ensembl | MGI Sequence Detail 326 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000009971 target of rapamycin complex subunit LST8
      (term hierarchy)
    • InterPro Domains
      IPR020472 PAC1/LIS1-like, WD-40 repeat
      IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
      IPR037588 Target of rapamycin complex subunit LST8
      IPR001680 WD40 repeat
      IPR019775 WD40 repeat, conserved site
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q9DCJ1 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1917593, MGI:2146758, MGI:2146886, MGI:2146940
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 6
      Gene Ontology 16
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:373724 Chowdhury O, et al., Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD-Like Pathology in Mice. Aging Cell. 2025 Jun;24(6):e70018
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory