Slc16a8 MGI Mouse Gene Detail - MGI:1929519 - solute carrier family 16 (monocarboxylic acid transporters), member 8

Symbol

Slc16a8
Name

solute carrier family 16 (monocarboxylic acid transporters), member 8
Synonyms

Mct3, proton-coupled monocarboxylate transporter 3

Feature Type

protein coding gene
IDs

MGI:1929519
NCBI Gene: 57274
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr15:79135214-79138961 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.70 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

212 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929519	protein coding gene	Chr15:79135214-79139619 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022069	protein coding gene	Chr15:79507711-79511458 (-)
A/J	MGP_AJ_G0022030	protein coding gene	Chr15:76767075-76770837 (-)
AKR/J	MGP_AKRJ_G0022005	protein coding gene	Chr15:78899507-78903260 (-)
BALB/cJ	MGP_BALBcJ_G0022036	protein coding gene	Chr15:76756269-76760028 (-)
C3H/HeJ	MGP_C3HHeJ_G0021807	protein coding gene	Chr15:78892753-78896510 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022479	protein coding gene	Chr15:82627988-82631733 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020009	protein coding gene	Chr15:73248906-73252671 (-)
CAST/EiJ	MGP_CASTEiJ_G0021328	protein coding gene	Chr15:79596867-79600598 (-)
CBA/J	MGP_CBAJ_G0021772	protein coding gene	Chr15:85185047-85188797 (-)
DBA/2J	MGP_DBA2J_G0021901	protein coding gene	Chr15:76245288-76249044 (-)
FVB/NJ	MGP_FVBNJ_G0021879	protein coding gene	Chr15:75277864-75282203 (-)
LP/J	MGP_LPJ_G0021969	protein coding gene	Chr15:79699659-79703405 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021899	protein coding gene	Chr15:90332751-90336499 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022493	protein coding gene	Chr15:78915999-78919747 (-)
PWK/PhJ	MGP_PWKPhJ_G0021070	protein coding gene	Chr15:76256187-76259986 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020907	protein coding gene	Chr15:78725581-78729337 (-)
WSB/EiJ	MGP_WSBEiJ_G0021380	protein coding gene	Chr15:79301226-79304976 (-)

Human Ortholog

SLC16A8, solute carrier family 16 member 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC16A8, solute carrier family 16 member 8
Synonyms

MCT3, REMP
Links

HGNC:16270

NCBI Gene ID: 23539

neXtProt AC: NX_O95907

UniProt: O95907
Chr Location

22q13.1; chr22:38078134-38084184 (-) GRCh38

MGI Vertebrate Homology

Slc16a8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC16A8
Gene Tree

Slc16a8

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Slc16a8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele exhibit reduced visual function, putatively due to changes in the ionic composition of the outer retina.

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All GO Annotations

11
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

7
cDNA Data

4
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN slc16a8

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All Sequences

34
RefSeq

4
UniProt

2
CCDS

CCDS27636.1

Ensembl

ENSMUSG00000032988 (Evidence)
NCBI Gene

57274

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032988	Ensembl Gene Model \| MGI Sequence Detail	3748	C57BL/6J	± kb
transcript	ENSMUST00000039752	Ensembl \| MGI Sequence Detail	1806	Not Applicable
polypeptide	ENSMUSP00000040522	Ensembl \| MGI Sequence Detail	492	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014956 monocarboxylate transporter 3

(term hierarchy)
InterPro Domains

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

IPR004743 Monocarboxylate transporter

IPR050327 Proton-linked Monocarboxylate Transporter

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All nucleic 8

cDNA 5

Primer pair 3

Microarray probesets 4

Summaries

All 58

Developmental Gene Expression 4

Diseases 1

Gene Ontology 9

Phenotypes 24
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27

TSS for Slc16a8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135318	Chr15:79138937-79138964 (-)	10 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24