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Rsad2 Gene Detail
Summary
  • Symbol
    Rsad2
  • Name
    radical S-adenosyl methionine domain containing 2
  • Synonyms
    2510004L01Rik, cig5, Vig1, viperin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929628
    NCBI Gene: 58185
  • Alliance
    gene page
  • Transcription Start Sites
    50 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:26492745-26506451 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 9.69 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    480 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929628
 protein coding gene Chr12:26492742-26506451 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019637
 protein coding gene Chr12:24177170-24190854 (-)
A/J MGP_AJ_G0019604
 protein coding gene Chr12:23546600-23560317 (-)
AKR/J MGP_AKRJ_G0019575
 protein coding gene Chr12:24304194-24317811 (-)
BALB/cJ MGP_BALBcJ_G0019581
 protein coding gene Chr12:23781400-23795113 (-)
C3H/HeJ MGP_C3HHeJ_G0019385
 protein coding gene Chr12:24195227-24208939 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017609
 protein coding gene Chr10:51989113-51998682 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017653
 protein coding gene Chr12:22978085-22991635 (-)
CAST/EiJ MGP_CASTEiJ_G0018940
 protein coding gene Chr12:19174792-19188518 (-)
CBA/J MGP_CBAJ_G0019356
 protein coding gene Chr12:25749240-25762950 (-)
DBA/2J MGP_DBA2J_G0019470
 protein coding gene Chr12:23360100-23373713 (-)
FVB/NJ MGP_FVBNJ_G0019461
 protein coding gene Chr12:23233807-23247516 (-)
LP/J MGP_LPJ_G0019540
 protein coding gene Chr12:24244916-24258627 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019496
 protein coding gene Chr12:25526183-25539927 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020068
 protein coding gene Chr12:23859009-23872722 (-)
PWK/PhJ MGP_PWKPhJ_G0018707
 protein coding gene Chr12:18113630-18127841 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018495
 protein coding gene Chr12:18361377-18375012 (-)
WSB/EiJ MGP_WSBEiJ_G0018991
 protein coding gene Chr12:24048750-24062366 (-)



Homology
more
  • Human Ortholog
    RSAD2, radical S-adenosyl methionine domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RSAD2, radical S-adenosyl methionine domain containing 2
  • Synonyms
    cig33, cig5, SAND, vig1
  • Links
    NCBI Gene ID: 91543
    neXtProt AC: NX_Q8WXG1
    UniProt: Q8WXG1

  • Chr Location
    2p25.2; chr2:6865557-6898239 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RSAD2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired T-helper 2 differentitation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    1
  • cDNA Data
    86
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020641 Ensembl Gene Model | MGI Sequence Detail 13707 C57BL/6J ±  kb
    transcript ENSMUST00000020970 Ensembl | MGI Sequence Detail 3782 Not Applicable  
    polypeptide ENSMUSP00000020970 Ensembl | MGI Sequence Detail 362 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 87
      cDNA 86
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1919695
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 4
      Gene Ontology 14
      Phenotypes 16
    • Earliest
      J:66317 Boudinot P, et al., vig-1, a new fish gene induced by the rhabdovirus glycoprotein, has a virus-induced homologue in humans and shares conserved motifs with the MoaA family. J Virol. 1999 Mar;73(3):1846-52
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory