About   Help   FAQ
Tg(Trp53R172H)8512Jmr
Transgene Detail
Summary
Symbol: Tg(Trp53R172H)8512Jmr
Name: transgene insertion 8512, Jeffrey Rosen
MGI ID: MGI:1929642
Synonyms: 172R-H, p53-172H, p53(R172H), Wap-p53R172H
Transgene: Tg(Trp53R172H)8512Jmr  Location: unknown  
Alliance: Tg(Trp53R172H)8512Jmr page
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Trp53R172H)8512Jmr expresses 1 gene
 
Mutation detailsThis transgene contains the rat whey acidic protein promoter and an allele of the mouse Trp53 mini-gene that carries a point mutation in codon 172 (CGC->CAC; Arg172His). (J:46426)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Tg(Trp53R172H)8512Jmr
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Notes
On an FVB/N background transgenic mice express TRP53 with both dominant-negative and a gain-of function properties.
References
Original:  J:46426 Li B, et al., A transgenic mouse model for mammary carcinogenesis. Oncogene. 1998 Feb 26;16(8):997-1007
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory