Terf2ip MGI Mouse Gene Detail - MGI:1929871 - telomeric repeat binding factor 2, interacting protein

Symbol

Terf2ip
Name

telomeric repeat binding factor 2, interacting protein
Synonyms

Rap1

Feature Type

protein coding gene
IDs

MGI:1929871
NCBI Gene: 57321
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:112738030-112747160 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 58.29 cM
Mapping Data

1 experiment

SNPs within 2kb

347 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929871	protein coding gene	Chr8:112737991-112747160 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034153	protein coding gene	Chr8:114852211-114863343 (+)
A/J	MGP_AJ_G0034133	protein coding gene	Chr8:110163527-110172287 (+)
AKR/J	MGP_AKRJ_G0034060	protein coding gene	Chr8:113411053-113421215 (+)
BALB/cJ	MGP_BALBcJ_G0034127	protein coding gene	Chr8:110340875-110350742 (+)
C3H/HeJ	MGP_C3HHeJ_G0033838	protein coding gene	Chr8:114115507-114127844 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034647	protein coding gene	Chr8:118861624-118870468 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031589	protein coding gene	Chr8:103234190-103243389 (+)
CAST/EiJ	MGP_CASTEiJ_G0033165	protein coding gene	Chr8:113761637-113777623 (+)
CBA/J	MGP_CBAJ_G0033811	protein coding gene	Chr8:122960430-122969011 (+)
DBA/2J	MGP_DBA2J_G0033967	protein coding gene	Chr8:109435659-109444012 (+)
FVB/NJ	MGP_FVBNJ_G0033910	protein coding gene	Chr8:108419160-108427298 (+)
LP/J	MGP_LPJ_G0034056	protein coding gene	Chr8:115004152-115014648 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033957	protein coding gene	Chr8:125790537-125800414 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034665	protein coding gene	Chr8:113395551-113411076 (+)
PWK/PhJ	MGP_PWKPhJ_G0032867	protein coding gene	Chr8:109048527-109057392 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032707	protein coding gene	Chr8:112048242-112056790 (+)
WSB/EiJ	MGP_WSBEiJ_G0033281	protein coding gene	Chr8:114086002-114096894 (+)

Human Ortholog

TERF2IP, TERF2 interacting protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TERF2IP, TERF2 interacting protein
Synonyms

DRIP5, RAP1
Links

HGNC:19246

NCBI Gene ID: 54386

neXtProt AC: NX_Q9NYB0

UniProt: Q9NYB0
Chr Location

16q23.1; chr16:75647773-75761872 (+) GRCh38

MGI Vertebrate Homology

Terf2ip stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TERF2IP
Gene Tree

Terf2ip

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Phenotype Summary

26 phenotypes from 4 alleles in 5 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

4
Gene trapped

8
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are fertile. Mice homozygous for a gene trapped allele die prior to E6.5 while heterozygous mice are resistant to LPS-induced mortality.

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All GO Annotations

51
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

747
Tissues

30
cDNA Data

41
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase terf2ip

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All Sequences

50
RefSeq

2
UniProt

2
CCDS

CCDS52678.1

Ensembl

ENSMUSG00000033430 (Evidence)
NCBI Gene

57321

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033430	Ensembl Gene Model \| MGI Sequence Detail	9131	C57BL/6J	± kb
transcript	ENSMUST00000052138	Ensembl \| MGI Sequence Detail	3560	Not Applicable
polypeptide	ENSMUSP00000052170	Ensembl \| MGI Sequence Detail	393	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016237 telomeric repeat-binding factor 2-interacting protein 1

(term hierarchy)
InterPro Domains

IPR001357 BRCT domain

IPR036420 BRCT domain superfamily

IPR009057 Homeobox-like domain superfamily

IPR015010 Rap1 Myb domain

IPR039595 TE2IP/Rap1

IPR021661 TRF2-interacting telomeric protein/Rap1, C-terminal

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All nucleic 44

cDNA 43

Primer pair 1

Microarray probesets 3

Summaries

All 58

Developmental Gene Expression 2

Gene Ontology 13

Phenotypes 20
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Terf2ip:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79512	Chr8:112737997-112738020 (+)	-21 bp
Tssr79513	Chr8:112738024-112738079 (+)	22 bp
Tssr79514	Chr8:112738085-112738099 (+)	62 bp
Tssr79515	Chr8:112745335-112745354 (+)	7,315 bp
Tssr79516	Chr8:112745474-112745500 (+)	7,457 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24