Cend1 MGI Mouse Gene Detail - MGI:1929898 - cell cycle exit and neuronal differentiation 1

Symbol

Cend1
Name

cell cycle exit and neuronal differentiation 1
Synonyms

1500001H12Rik, BM88

Feature Type

protein coding gene
IDs

MGI:1929898
NCBI Gene: 57754
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr7:141006359-141009404 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 86.77 cM, cytoband F5
Mapping Data

3 experiments

SNPs within 2kb

147 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929898	protein coding gene	Chr7:141006359-141009475 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033228	protein coding gene	Chr7:146615090-146618135 (-)
A/J	MGP_AJ_G0033210	protein coding gene	Chr7:142420354-142423400 (-)
AKR/J	MGP_AKRJ_G0033142	protein coding gene	Chr7:146370525-146373571 (-)
BALB/cJ	MGP_BALBcJ_G0033211	protein coding gene	Chr7:142165542-142168587 (-)
C3H/HeJ	MGP_C3HHeJ_G0032925	protein coding gene	Chr7:146110731-146113778 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033722	protein coding gene	Chr7:151966450-151969495 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030695	protein coding gene	Chr7:143632497-143635543 (-)
CAST/EiJ	MGP_CASTEiJ_G0032255	protein coding gene	Chr7:138422704-138425769 (-)
CBA/J	MGP_CBAJ_G0032897	protein coding gene	Chr7:157130785-157133832 (-)
DBA/2J	MGP_DBA2J_G0033049	protein coding gene	Chr7:140368755-140371801 (-)
FVB/NJ	MGP_FVBNJ_G0033002	protein coding gene	Chr7:140283122-140286168 (-)
LP/J	MGP_LPJ_G0033144	protein coding gene	Chr7:148111123-148114168 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033035	protein coding gene	Chr7:157761645-157764691 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033742	protein coding gene	Chr7:145329053-145332099 (-)
PWK/PhJ	MGP_PWKPhJ_G0031959	protein coding gene	Chr7:133652906-133655976 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031806	protein coding gene	Chr7:132165963-132169032 (-)
WSB/EiJ	MGP_WSBEiJ_G0032366	protein coding gene	Chr7:146279569-146282642 (-)

Human Ortholog

CEND1, cell cycle exit and neuronal differentiation 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CEND1, cell cycle exit and neuronal differentiation 1
Synonyms

BM88
Links

HGNC:24153

NCBI Gene ID: 51286

neXtProt AC: NX_Q8N111

UniProt: Q8N111
Chr Location

11p15.5; chr11:787115-790113 (-) GRCh38

MGI Vertebrate Homology

Cend1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CEND1
Gene Tree

Cend1

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Radiation induced

1
Targeted

2
Genomic Mutations

1 involving Cend1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display impaired cerebellar development with defects in granule cell proliferation and migration and purkinje cell arborization. These defects result in a thin cerebellar molecular layer and impaired coordination in adults.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1006
Tissues

41
cDNA Data

25
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

38
RefSeq

4
UniProt

1
CCDS

CCDS22012.1

Ensembl

ENSMUSG00000060240 (Evidence)
NCBI Gene

57754

			Length	Strain/Species	Flank
genomic	ENSMUSG00000060240	Ensembl Gene Model \| MGI Sequence Detail	3046	C57BL/6J	± kb
transcript	ENSMUST00000084436	Ensembl \| MGI Sequence Detail	1672	Not Applicable
polypeptide	ENSMUSP00000081476	Ensembl \| MGI Sequence Detail	149	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005322 cell cycle exit and neuronal differentiation protein 1

(term hierarchy)
InterPro Domains

IPR020162 Cell cycle exit/neuronal differentiation protein 1

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All nucleic 27

cDNA 25

Primer pair 2

Microarray probesets 7

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MGI:1916208, MGI:2141931

Summaries

All 40

Developmental Gene Expression 7

Gene Ontology 6

Phenotypes 8
Earliest

J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
Latest

J:344312 Liu H, et al., Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development. iScience. 2024 Jan 19;27(1):108722

TSS for Cend1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr75649	Chr7:141009471-141009478 (-)	-71 bp
Tssr75648	Chr7:141009346-141009368 (-)	47 bp
Tssr75647	Chr7:141009267-141009342 (-)	99 bp
Tssr75646	Chr7:141007912-141007921 (-)	1,487 bp
Tssr75645	Chr7:141007414-141007434 (-)	1,980 bp
Tssr75644	Chr7:141007333-141007353 (-)	2,061 bp
Tssr75643	Chr7:141007281-141007303 (-)	2,112 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24